A Histopathological Study of Non-Neoplastic and Neoplastic Lesions in Nephrectomy Specimens
Keywords:Nephrectomy ;Chronic Pyelonephritis; Hydronephrosis; Clear Cell Renal Cell Carcinoma.
Background: The kidneys are affected by various disease processes some resulting in permanent damage which may need surgical removal of the organ by partial or total nephrectomy1. Indications for nephrectomy are varied with common indication being obstructive nephropathy, hydronephrosis and chronic pyelonephritis according to studies1.
Aims and Objective: This study was conducted to evaluate the neoplastic and non neoplastic conditions encountered in nephrectomy specimens that were received in our department over a one and half year period. To analyze the frequency of non neoplastic and neoplastic renal lesions, assess age and sex wise distribution of various renal lesions and compare it with other studies.
Materials and Method: The present study was done for a period of 1.5 year from January 2018 to June 2019.A total of 55 nephrectomy specimens were received in the Department of Pathology, B.J.M.C Medical college & Civil Hospital, Ahmedabad India. The clinical details and gross morphology along with microscopic details were recorded. Immunohistochemistry was not done. The results were tabulated.
Findings : In our study, out of 55 nephrectomy specimens , 41 were non-neoplastic and 14 were neoplastic. Males constituted 20 cases(36.36%), females 35 cases(63.63%). The M:F ratio being 0.57 .The highest percentage of patients in both non-neoplastic and neoplastic categories belonged to 2th and 3th decade. A majority of cases were that of chronic pyelonephritis were seen maximum in the age group 21-30 years. Maximum number of Renal cell carcinoma fell into the age group of 51-60 years.
Conclusion: Most common affected age group was 2nd and 3rd decade. Non-neoplastic lesions were most common cause for nephrectomies. Chronic pyelonephritis with hydronephrotic changes being the most common cause. Clear cell renal cell carcinoma being the common among malignant tumors.