Histomorphological Spectrum of Meningiomas in A Tertiary Care Hospital in Ahmedabad
Keywords:Meningioma, Histopathology, WHO Grading.
Introduction: Meningiomas are predominantly benign tumors of adults; most often encountered in middle or later adult life. This tumor is mostly attached to inner aspect of dura and graded by WHO (World Health Organization) as Grade I, II, and III. The higher grade meningiomas have a greater likelihood of recurrence and aggressive behaviour. Meningiomas produce neurological signs and symptoms due to compression of adjacent structures. A few histological features and variants are associated with aggressive behavior and high risk of recurrence.
Material & Method: This is a prospective study comprised of 50 cases received in Department of Surgical Pathology, B.J. Medical College, Ahmedabad during period of November 2018 to October 2019 (1 year).
Results: Out of 50 cases, most common age group was 30-50 yrs. M:F ratio was 4:1. Most cases (94%) were intracranial. Most common chief presenting complain was headache (30% cases) followed by seizures (20% cases). Most common histomorphological pattern was Meningothelial meningioma(32%) followed by Psammomatous meningioma(22%). 90% cases belonged to WHO Grade I, 6% were Grade II and 4% Grade III.
Conclusion: Meningiomas display a wide diversity of histopathological appearances. The majority are benign and hence curable by surgical resection. Few high grade meningiomas require radiotherapy after surgical excision and hence histological diagnosis and grading is essential.