Diagnostic Utility of Fluid Cytology in a Tertiary Care Hospital
Keywords:Neoplastic, Malignancy, Adenocarcinoma
Introduction: Cytological examination of body fluids is an inexpensive and useful tool to assist in diagnosis of neoplastic and non–neoplastic lesions in the body, understanding course of a disease or monitoring response to therapy. The present study aims at studying the morphological spectrum of various body fluids received and processed at the Department of Cytopathology, B.J. Medical College, Ahmedabad, Gujarat. The study period is March 1, 2018 to February 28, 2019.
Material and Method: The fluid samples were received at the Department of Cytopathology. Cerebrospinal fluid and urine samples were processed by cytospin method and all other body fluids were centrifuged. The sediment separated from the above procedure was used in preparation of smears on glass slides with frosted ends and stained with Papanicolaou’s, Hematoxylin and Eosin and May Grunwald Giemsa stains. The stained slides were then examined under binocular microscope and reported.
Result: The total number of body fluids received during the above mentioned study period was 491, out of which the most common aspirated fluid was Peritoneal fluid (51.73%), followed by Pleural fluid (34.22%), Broncho-alveolar lavage fluid (3.87%), Cerebrospinal fluid (3.46%), Nipple discharge fluid (3.26%), Urine (2.04%) and Ovarian cyst fluid (1.43%). Out of the total, 13 (2.65%) were reported as ‘positive for malignancy’ and 14 (2.85%) were reported as ‘suspicious for malignancy’, maximum being reported in peritoneal fluid. Adenocarcinoma was the most common malignancy in our study.
Conclusion: Fluid cytology is a rapid, effective and inexpensive method of diagnosis and evaluation, and it further helps in making clinical decision regarding management of the underlying pathology.