Spectrum of Non-neoplastic Skin Lesions: A Histopathological Study based on Punch Biopsy (A Study of 200 Cases)
Keywords:Accurate diagnosis, Punch biopsy, Non-neoplastic skin lesions
Introduction: Accurate diagnosis of skin is of utmost importance for management of different skin
disorders presenting with the similar clinical signs and symptoms. Therefore to confirm the diagnosis and
start treatment biopsy becomes inevitable and for obtaining diagnostic full-thickness skin specimens Punch
biopsy is the primary method.
Aims & Objective: The present study was to analyse the incidence and age & sex distribution of dermatological
disorders presenting to B.J. Medical College, Civil Hospital Ahmedabad (tertiary care centre), Gujarat and
access their histopathological profile
Materials & Methods: This was a retrospective study carried out at the department of Pathology B.J.
Medical College & Civil Hospital, Ahmedabad for a period of 1 year (1st January 2018 to 31st December
2018). With necessary clinical details obtained in a proforma, punch biopsy specimen is sent to the
histopathology section for final diagnosis. Formalin fixed, paraffin embedded sections were prepared &
slides were routinely stained with H & E and special stains applied wherever necessary. Data obtained was
tabulated and analysed.
Results: Total 232 cases were analysed. 21-30 years age group constituted 22% of the total cases. Male/
Female ratio is 61/39. Hypopigmented patch/plaque was the most common clinical lesion (27%). Hansen’s
disease was the most common histopathological diagnosis reported (30%) followed by vesiculobullous
Conclusion: Punch biopsy is a very simple outdoor procedure and very useful for skin lesions. Hansen’s
disease is still most common skin disease for which biopsy is done followed by vesiculobullous lesion.
Tattoo induced granuloma is also a common lesion along with lichenoid lesion.