Polymorphism in Superoxide Dismutase, Catalase Genes and Their Role in Cervical Cancer Susceptibility among Rural Population of Maharashtra: Findings from A Hospital based Case Control Study

Authors

  • Kailas D. Datkhile1 , Anand Gudur2 , Rashmi A. Gudur3 , Madhavi N. Patil4 , Pratik P. Durgawale5 , Vinit N. Deshmukh6 , Nilam J. Jagdale6

DOI:

https://doi.org/10.37506/ijfmt.v14i3.10386

Keywords:

Genetic polymorphism, Superoxide dismutase, Catalase, Cervical cancer.

Abstract

Background: The present study was planned to investigate the possible association between polymorphisms

of superoxide dismutase, SOD1 (Cu,Zn-SOD), SOD2(Mn-SOD), SOD3(EC-SOD) and catalase genes and

the risk of cervical cancer in rural population of Maharashtra.

Methods: A case control study included 350 proven cervical cancer cases and 400 healthy age matched

control women. Genotyping of isoforms of SOD and CAT were done by polymerase chain reaction

restriction fragment length polymorphism (PCR-RFLP) method.

Results: When we studied genotype frequencies of codon 326 and 262 region of promoter of CAT gene,

there was no significant association between A to T transition at codon 326 (p=0.45) and CAT C262T

polymorphism (p=0.30) with susceptibility to cervical cancer. The variant G allele of SOD1 at codon 251

significantly increased in cervical cancer patients as compared with the control women (OR=3.02, 95% CI:

1.72-5.31; p<0.0001).

Conclusion: Findings from this investigation confirms conceivable association of A251G of SOD1 and

G172A of SOD3 genes with risk of cervical cancer in women of Maharashtra.

Author Biography

Kailas D. Datkhile1 , Anand Gudur2 , Rashmi A. Gudur3 , Madhavi N. Patil4 , Pratik P. Durgawale5 , Vinit N. Deshmukh6 , Nilam J. Jagdale6

1 Senior Research Officer, Department of Molecular Biology & Genetics, 2Professor, Department of Oncology, 3 Assistant Professor, Department of Oncology, 4 Junior Research Officer, 5 Research Officer, 6 Research Assistant, Department of Molecular Biology & Genetics, Krishna Institute of Medical Sciences “Deemed University”, Taluka-Karad, Dist-Satara, (Maharashtra) India

Published

2020-07-30

How to Cite

Kailas D. Datkhile1 , Anand Gudur2 , Rashmi A. Gudur3 , Madhavi N. Patil4 , Pratik P. Durgawale5 , Vinit N. Deshmukh6 , Nilam J. Jagdale6. (2020). Polymorphism in Superoxide Dismutase, Catalase Genes and Their Role in Cervical Cancer Susceptibility among Rural Population of Maharashtra: Findings from A Hospital based Case Control Study. Indian Journal of Forensic Medicine & Toxicology, 14(3), 366-371. https://doi.org/10.37506/ijfmt.v14i3.10386