Polymorphism in Superoxide Dismutase, Catalase Genes and Their Role in Cervical Cancer Susceptibility among Rural Population of Maharashtra: Findings from A Hospital based Case Control Study
DOI:
https://doi.org/10.37506/ijfmt.v14i3.10386Keywords:
Genetic polymorphism, Superoxide dismutase, Catalase, Cervical cancer.Abstract
Background: The present study was planned to investigate the possible association between polymorphisms
of superoxide dismutase, SOD1 (Cu,Zn-SOD), SOD2(Mn-SOD), SOD3(EC-SOD) and catalase genes and
the risk of cervical cancer in rural population of Maharashtra.
Methods: A case control study included 350 proven cervical cancer cases and 400 healthy age matched
control women. Genotyping of isoforms of SOD and CAT were done by polymerase chain reaction
restriction fragment length polymorphism (PCR-RFLP) method.
Results: When we studied genotype frequencies of codon 326 and 262 region of promoter of CAT gene,
there was no significant association between A to T transition at codon 326 (p=0.45) and CAT C262T
polymorphism (p=0.30) with susceptibility to cervical cancer. The variant G allele of SOD1 at codon 251
significantly increased in cervical cancer patients as compared with the control women (OR=3.02, 95% CI:
1.72-5.31; p<0.0001).
Conclusion: Findings from this investigation confirms conceivable association of A251G of SOD1 and
G172A of SOD3 genes with risk of cervical cancer in women of Maharashtra.
Published
How to Cite
Issue
Section

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
https://creativecommons.org/licenses/
CC BY
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions