Association between IL12A Gene of G/A genotype Polymorphism and Pulmonary Tuberculosis Risk in Baghdad Population
Keywords:IL12A Gene, Pulmonary Tuberculosis, Polymorphisms, Tetra-ARMS PCR
The study included eighty samples. This cases-controlled study was performed including fifty Pulmonary
tuberculosis patients, their ages ranged from 12 to 77 year (27 female and 23 male) and thirty controls
(healthy), their ages ranged from 19 to 58 year (15 female and 15 male). We confined the frequency of
IL12A gene (G/A rs568408 genotype) polymorphism by Tetra-ARMS PCR (Tetra amplification refractory
mutation system-polymerase chain reaction) technology. Also, we determined the association of IL12A
Gene (G/A rs568408 genotype) polymorphism with Pulmonary tuberculosis patients in Baghdad. Statistical
results showed significant difference in genotype frequency of IL12A Gene (G/A rs568408 genotype)
polymorphism between Pulmonary tuberculosis patients and control (healthy). The G allele shows high
frequency in Pulmonary tuberculosis patients comparison with control (healthy) and present related with
etiological fraction risk of Pulmonary tuberculosis patients and its ratio 62% in patients and 51.67% in
control (healthy), While A allele shows high frequency in control (healthy) comparison with Pulmonary
tuberculosis patients and present related with protective fraction of Pulmonary tuberculosis patients and
its ratio 48.33% in control and 38% in Pulmonary tuberculosis patients. The genotypes of GG and AA
homozygotes shows high frequency in Pulmonary tuberculosis patients comparison with control (healthy),
and its ratio 42% and 18% respectively in Pulmonary tuberculosis patients, while its ratio 3.33% and 0%
respectively in control (healthy), also GG and AA genotypes appear related with etiological fraction risk of
Pulmonary tuberculosis patients, while the GA heterozygote show high frequency in control (healthy) and its
ratio 96%, GA genotypes related with preventive fraction of Pulmonary tuberculosis patients. Our findings
demonstrate that the IL12A Gene (G/A rs568408 genotype) polymorphism may represent a significant risk
factor for pulmonary tuberculosis patients in Baghdad population.
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