Pharmacological Effects of Dexamethasone in Rats
Keywords:Dexamethasone, Rats, intraperitoneally.
Dexamethasone is one of the most widely used glucocorticoids which has a prominent glucocorticoid with
slight mineralocorticoid property. This study was performed on twenty four adult Sprague Dawley rats
to evaluate the proposed effects of dexamethasone offering as intraperitoneal injection. The animals were
allocated randomly into three groups of eight rats to each. The protocol of experiment was: the control group;
animals are injected intraperitoneally with 2ml of distilled water, the dexamethasone 1 group; animals are
injected intraperitoneally with dexamethasone 2mg/kg, and the dexamethasone 2 group; animals are injected
intraperitoneally with dexamethasone 4mg/kg. The injection period extended for one month. The results
illustrate that dexamethasone cause significant declination in RBC, PCV, Hb, HDL, and neutrophils besides
significant elevations in WBC, eosinophils, monocytes, LDL, TC, TG, VLDL, AST, ALT, and creatinine
on a direct positive proportion with the increase in dexamethasone dose comparing with control group at
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