Role of Interleukin-36 in Response to Pseudomonas Aeruginosa Infection
Keywords:IL36, Pseudomonas aeruginosa, LRT infection and A549 cells
Background: One of the causative agents of the lower respiratory tract (LRT) is Pseudomonas aeruginosa
which can lead to severe infection associated with a lung infection. Many cytokines are secreted in response
to bacterial infection, in particular, interleukin IL-36 cytokine in response to P. aeruginosa infection. IL36
promotes primary immune response via binding to the IL-36 receptor (IL-36R). Indeed, an over activity of
IL-36 might be an initiating factor for many immunopathologic sceneries in pneumonia.
The aims of Study: the involvement of IL-36 in the P. aeruginosa infection could be a clue to find a specific
way for treatments of different inflammatory and degenerative lung diseases.
Methodology and Results: we used manual and VITEK2 system to isolate and purify all the species, also
using qPCR real-time to demonstrate that the involvement of IL-36 cytokine in response P. aeruginosa
infection which is isolated from (LRT). We found that one of the most common pathogens is P. aeruginosa
after Klebsiella pneumonia, and more resistance bacterium against antibiotics is P. aeruginosa (P4).
Furthermore, we found that IL-36 cytokine increased in response to P. aeruginosa infection.
Conclusion: P. aeruginosa is one of the main causative agents in LRT in many hospitals in Iraq, and the
contamination and antibiotics resistance for these nosocomial pathogens is increased. Also, IL-36 expression
significantly upregulated in human lung epithelial (A549 cells) after infected by P. aeruginosa at the mRNA
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