Renal Protective Effects of Gamma-Mangostin in Streptozotocin-Induced Diabetic Mice
Keywords:antioxidant activity, diabetes mellitus, gamma-mangostin.
This study was aimed to investigate the ability of gamma-mangostin to reduce plasma blood urea nitrogen
(BUN) and creatinine and ameliorates the impaired renal proximal tubular cells in diabetic mice. Antioxidant
assay was conducted by using male BALB/c mice. Mice were divided into two groups, they were normal
control (KN) and streptozotocin-induced diabetic mice. Streptozotocin (STZ) induction was performed
using multiple low-dose of 30 mg/kg body weight injected for five consecutive days. Diabetic mice have
divided into three subgroups; diabetic control (KD), diabetic mice treated with acarbose (KA), and diabetic
mice treated with gamma-mangostin. The gamma-mangostin treatment group was categorized based on the
dose given; P1 (1 mg/kg BW), P2 (2 mg/kg BW), and P3 (4 mg/kg BW). Interestingly, gamma-mangostin
administration was found to be able to lower plasma BUN and creatinine and ameliorate the impaired renal
proximal tubular cells in diabetic mice significantly. Therefore, gamma-mangostin has demonstrated high
antioxidant activity. The proof suggests that gamma-mangostin is a lead compound candidate for clinical
management or prevent diabetes mellitus.
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