Renal Protective Effects of Gamma-Mangostin in Streptozotocin-Induced Diabetic Mice

Authors

  • Saikhu Akhmad Husen1,2, Salamun1 , Arif Nur Muhammad Ansori3 , Suhailah Hayaza4 , Raden Joko Kuncoroningrat Susilo4 , Dwi Winarni1,2, Win Darmanto5

DOI:

https://doi.org/10.37506/ijfmt.v14i3.10562

Keywords:

antioxidant activity, diabetes mellitus, gamma-mangostin.

Abstract

This study was aimed to investigate the ability of gamma-mangostin to reduce plasma blood urea nitrogen

(BUN) and creatinine and ameliorates the impaired renal proximal tubular cells in diabetic mice. Antioxidant

assay was conducted by using male BALB/c mice. Mice were divided into two groups, they were normal

control (KN) and streptozotocin-induced diabetic mice. Streptozotocin (STZ) induction was performed

using multiple low-dose of 30 mg/kg body weight injected for five consecutive days. Diabetic mice have

divided into three subgroups; diabetic control (KD), diabetic mice treated with acarbose (KA), and diabetic

mice treated with gamma-mangostin. The gamma-mangostin treatment group was categorized based on the

dose given; P1 (1 mg/kg BW), P2 (2 mg/kg BW), and P3 (4 mg/kg BW). Interestingly, gamma-mangostin

administration was found to be able to lower plasma BUN and creatinine and ameliorate the impaired renal

proximal tubular cells in diabetic mice significantly. Therefore, gamma-mangostin has demonstrated high

antioxidant activity. The proof suggests that gamma-mangostin is a lead compound candidate for clinical

management or prevent diabetes mellitus.

Author Biography

Saikhu Akhmad Husen1,2, Salamun1 , Arif Nur Muhammad Ansori3 , Suhailah Hayaza4 , Raden Joko Kuncoroningrat Susilo4 , Dwi Winarni1,2, Win Darmanto5

1 Associate Professor, Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya,

60115, Indonesia, 2Researcher, Animal Histology Laboratory, Faculty of Science and Technology, Universitas

Airlangga, Surabaya, 60115, Indonesia, 3Doctoral Student, Doctoral Program in Veterinary Science, Faculty of

Veterinary Medicine, Universitas, Airlangga, Surabaya, 60115, Indonesia. 4 Doctoral Student, Doctoral Program

in Mathematics and Natural Sciences, Faculty of Science and Technology, Universitas Airlangga, Surabaya,

60115, Indonesia, 5 Professor, Department of Biology, Faculty of Science and Technology, Universitas Airlangga,

Surabaya, 60115, Indonesia

Published

2020-07-30

How to Cite

Saikhu Akhmad Husen1,2, Salamun1 , Arif Nur Muhammad Ansori3 , Suhailah Hayaza4 , Raden Joko Kuncoroningrat Susilo4 , Dwi Winarni1,2, Win Darmanto5. (2020). Renal Protective Effects of Gamma-Mangostin in Streptozotocin-Induced Diabetic Mice. Indian Journal of Forensic Medicine & Toxicology, 14(3), 1251-1256. https://doi.org/10.37506/ijfmt.v14i3.10562