An in Vitro Study to Evaluate Antibacterial Effect Thymus Vulgaris Essential Oil Against Porphyromonas Gingivalis in Kurdistan– Iraq
Keywords:Porphyromonas gingivalis, Thymus vulgaris, minimum inhibitory concentration, periodontitis.
Purpose: Porphyromonas gingivalis is a keystone among perio-pathogengenic bacteria to initiate
periodontitis and treatment is better when the periodontal pathogens including Porphyromonas gingivalis
are totally eliminated. The essential oil of Thymus vulgaris has many bioactive constituents having
antimicrobial activity against many bacteria. This study investigates the antibacterial effect of this extracts
against Porphyromonas gingivalis. Methods: Sub gingival plaque samples were collected from individuals
having periodontitis with the probing pocket depth of at least 6mm; Conventional microbiological tests and
molecular technique used for confirmation of Porphyromonas gingivalis, hydrodistillation method was used
for extraction of essential oil. Antibacterial activity of the extract against Porphyromonas gingivalis has been
determined by using two fold serial dilution method to determine minimum inhibitory concentration (MIC)
and minimum bactericidal concentration (MBC). Result: the essential oil extracted from Thymus vulgaris
demonstrated antimicrobial effect against Porphyromonas gingivalis growth. Conclusion:The extract was
able to demonstrate inhibitory and bactericidal activity against Porphyromonas gingivalis. Further studies
should focus on the use of Thymus vulgaris essential oil in the treatment of periodontitis.
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