The Correlation between Myelucleopidase Levels and the Event of the Acute Coronary Syndrome

Authors

  • Citra Indah Setyaningrum1 , Jusak Nugraha1, Muhammad Aminuddin1

Keywords:

sindroma coroner, infark miokard akut, unstable angina, nekrosis miokard.

Abstract

Background: Acute coronary syndrome (ACS) is a collection of symptoms due to cardiac blood flow

disorders consisting of acute myocardial infarction (AMI) with increased ST segment (STEMI), AMI

without increased ST segment (NSTEMI) and unstable angina pectoris (UA). Myeloperoxidase (MPO) is

an enzyme that plays a role in the destabilization and rupture of plaque that rises earlier within 2 hours

after AMI attack so it can be used as an early marker of ACS without depending on evidence of myocardial

necrosis. So, the purpose of this study is to determine the relationship between MPO levels and ACS events.

Methods: This study is using quantitative method. Research sample was 40 patients serum with the main

complaint of chest pain that fulfilled the inclusion criteria who came to the emergency unit of Dr.Soetomo

General Hospital Surabaya. The blood samples were examined for MPO with MPO kit from Quanticine (R

& D system) using ELISA method. The diagnostic value obtained from the calculation with the 2x2 table.

Results: Patients with chest pain were 27 persons (67.5%), while non-ACS patients were 13 persons

(32.5%). There were significant differences in MPO levels between the STA (STEMI, NSTEMI, UA) groups

of 986.48 ng/ml and non-ACS 381.08 ng/ml (p = 0.002). Diagnostic sensitivity was 88.88%, diagnostic

specificity 69.23%, negative predictive value 75% and positive predictive value 85.71%. The correlation

coefficient between MPO and ACS content is r = 0.45 with p = 0.003.

Conclusion: There was a correlation between MPO levels and the incidence of ACS. The higher the MPO

level the higher the incidence of ACS.

Author Biography

Citra Indah Setyaningrum1 , Jusak Nugraha1, Muhammad Aminuddin1

1 Research Scholat in Dr.Soetomo Teaching Hospital, Universitas Airlangga, Surabaya. 60285, Indonesia, 1Lecture

in Department of Clinical Pathology, Faculty of Medicine, Dr.Soetomo Teaching Hospital, Universitas Airlangga,

Surabaya. 60285, Indonesia

Published

2020-07-30

How to Cite

Citra Indah Setyaningrum1 , Jusak Nugraha1, Muhammad Aminuddin1. (2020). The Correlation between Myelucleopidase Levels and the Event of the Acute Coronary Syndrome. Indian Journal of Forensic Medicine & Toxicology, 14(3), 1827-1831. Retrieved from http://medicopublication.com/index.php/ijfmt/article/view/10683