Correlation between High Sensitivity-Crp Level and Executive Function Disorders in Elderly Patients
Keywords:High hs-CRP, Executive Function, Elderly Patient
Background: C-Reactive Protein is a marker of inflammation and vascular disease. The high serum of high
sensitivity C-Reactive Protein (hs-CRP) concentration was associated with interruption the integrity of the
Objective: To determine the correlation between high serum concentration of hs-CRP and executive function
disorder in elderly patients.
Method: Thirty six elderly patients was examined by using a case control study. The subjects were enrolled
from the out-patient at Neurology Departement Dr. Soetomo General Hospital, Surabaya, Indonesia. The
time period was 4 months (April to July 2015). Executive function was measured with the Trail Making
Test B (TMT B) and divided into two groups, case and control. Complete blood count and serum hs-CRP
concentration were measured from nonfasting blood samples. Chi-square test was used for data analysis.
Results: Eighteen subjects were enrolled in the case group (3 men, 15 women) and the other 18 subjects
were enrolled in the control group (4 men, 14 women). Executive function disorder was found in 17 (94,4%)
subjects of case group and 11 (61,1%) subjects of control group. High levels of hs-CRP was not associated
with executive function, with p = 0,149 and adjusted OR 5,629 (CI 95% 0,538-58,860).
Conclusion: These data suggested that high levels of hs-CRP was not associated with executive function in
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