Characteristics Nanoparticle of Propolis Ethanol Extracts with Variations of Chitosan-Sodium Alginat
Keywords:Propolis, Nanoparticles, Chitosan-Sodium Alginate, Absorption Efficiency
Nanoencapsulation technology has many advantages, which include important roles in drug delivery and
protection of bioactive components that have perishable stability, one of which is polyphenol compounds.
Propolis which contains high levels of polyphenol compounds has been used as an antioxidant for various
diseases. By making nanoparticles from propolis, it can maintain the stability of polyphenol compounds
from propolis and increase the effect of treatment through optimal delivery. Nanoformulations containing
ethanol extract of propolis were absorbed by chitosan-sodium alginate using an ionotropic pre-gelation
method. Optimization is carried out at various concentrations of chitosan, namely 0.05%; 0.075%; 0.1% and
0.125% , with the use of the same sodium alginate concentration which is 0.0063%. Testing of nanoparticle
characteristics includes particle size and morphology and adsorption efficiency (EE) consisting of total
flavonoid and total polyphenol values. The increase in chitosan polymer is directly proportional to the
increase in particle size, but does not occur in the absorption efficiency value. The 0.05% chitosan formula
showed the absorption of polyphenol compounds at 99.41% with particle sizes of 259.12 nm
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