Effect of Methamphetamine Addiction on Brain Chemistry Through the Adoption of Fractalkine as an Indicator
Keywords:CX3CL1. Fractalkine .CX3CR1. Chemokines. Methamphetamine. blood–brain barrier (BBB).
Methamphetamine (METH), a highly addictive drug and a strong stimulant of the central nervous system.
METH abuse is increasing, especially among young people and adolescents, and therefore we wanted in this
research to shed light on some of the problems resulting from meth use, especially its effect on the central
nervous system, the blood-brain barrier, and Fractalkine (CX3CL1).
CX3CL1 is the only member of the CX3C subcategory of chemokines, which have a major role in the
central nervous system by regulating interactions between neurons, glial cells, and immune cells. It is also
considered heavily involved in traumatic brain injury (TBI) and spinal cord injury (SCI).
The study was conducted on eighty people divided into three groups, thirty non addicted men as a control
group(G1), taking into account and excluding, cigarette smoking, age, social and cultural conditions, and
chronic diseases, also thirty people addicted to methamphetamine(G2), and twenty people addicted to
methamphetamine and other narcotic substances (mix)(G3), whose ages ranged between (15-45) years and
the period of methamphetamine abuse ranged between (1-7) years.
The results of study showed that CX3CL1 values were higher among addicted persons compared to non
addicts (G1), this difference in values shows us the effect of meth on the total values of CX3CL1.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions