Investigation the Association of the VEGFR-2 and -2578C\A Polymorphism as a Risk Factor for Incidence of Lung Cancer in Babylon Province

Authors

  • Ali K. Dahir1 , Alaa S. Al-Awad2 , Moaed E. Al-Gazally3

DOI:

https://doi.org/10.37506/ijfmt.v14i3.10794

Keywords:

Lung cancer, VEGFR-2, polymorphism, dominant model.

Abstract

Background: VEGF gene polymorphisms can induce either increase or inhibition of VEGF secretion, with

altered promoter activity.

Aim: We investigated the association of the VEGFR-2 and -2578C\A polymorphism in the VEGF gene with

Lung cancer risk in Babylon province. Methodology: VEGFR-2 level was measured by Enzyme Linked

Immunoabsorbant Assay ELISA and Genotyping of the VEGF-gene variation (-2578A\C) was performed

using the amplification refractory mutation system PCR. We investigated the association of VEGF gene

variants with different clinicopathological features of lung cancer patients.

Results: No significant difference was seen of the VEGFR-2 levels in lung cancer patients when compared

with control group (P=092), the allelic frequency of -2578 A\C VEGF gene no difference was seen in patients

lung cancer (p=0.652). Hardy-Weinberg equilibrium showed a significant difference cases group (p=0.016),

also revealed A allele exhibits a pathological behavior and it appears in over-dominant model (p=0.05), this

proves that there is significant association of -2578A\C VEGF gene in lung cancer patients.

Conclusion: Our results showed no significant association of the VEGFR-2 in lung cancer patients

while showed a significant association of the VEGF -2578C\A polymorphism with LC susceptibility in

Babylon province .The VEGF -2578C\A heterozygote significantly increases the risk and can be useful as a

predisposing genetic marker.

Author Biography

Ali K. Dahir1 , Alaa S. Al-Awad2 , Moaed E. Al-Gazally3

1College of Medicine, Babylon University, Iraq, 2Prof. Dr., Oncology Center, Merjan Teaching Hospital, Babylon,

Iraq, 3 Prof. Dr., College of Medicine, Babylon University, Work Now at University of Al-Ameed, Iraq

Published

2020-07-30

How to Cite

Ali K. Dahir1 , Alaa S. Al-Awad2 , Moaed E. Al-Gazally3. (2020). Investigation the Association of the VEGFR-2 and -2578C\A Polymorphism as a Risk Factor for Incidence of Lung Cancer in Babylon Province. Indian Journal of Forensic Medicine & Toxicology, 14(3), 2391-2396. https://doi.org/10.37506/ijfmt.v14i3.10794