Histological Evaluation of the Effect of Metronidazolemedicine on the Brain Tissue in Adult Female White Rats

Authors

  • Yaseen Khalaf Mohammed1 , Ayad Hameed Ibrahim2 , Aziz Khalid Hameed3

DOI:

https://doi.org/10.37506/ijfmt.v14i3.10799

Keywords:

Metronidazole, Brain, Pregnant, Neurotoxic, Hyperplasia, Vacuolation, pyknosis.

Abstract

The present study was undertaken to assess the neurotoxic effect of metronidazole in pregnant female rats .

Twenty adult pregnant female rats were randomly divided into four groups treatment with oral metronidazole

at the therapeutic dose 250 mg/kg, 500 mg/kg and 1000 mg/kg from the eight day of pregnant to the

twenty day of pregnant (every eight hour), whereas the last group serve as a control. Routine Histological

Techniques were done and stained by Hematoxylin and Eosin (H & E). The histopathological examination

of brain show the lesion was characterized by a wide spongy cavitation and cavitation was observed around

the nerve and glial cells along with atrophy of some of its nuclei and around the axonal and vascular axons

with the presence of nuclear thickening of some glia cells, as well as hyperplasia of the glial cells supporting,

disintegration and degeneration of nerve fibers, with damage to the meninges. In addition to the presence of

bloody congestion. This study revealed that metronidazole have a neurotoxic effect in adult female rats with

a severity depended on its dose and duration of administration.

Author Biography

Yaseen Khalaf Mohammed1 , Ayad Hameed Ibrahim2 , Aziz Khalid Hameed3

1 Researcher: Department of Biology-College of Science, Tikrit University/Iraq, 2Prof. Dr: Department of Anatomy

and Histology-College of Veterinary Medicine- Tikrit University/Iraq, 3Prof. Dr: Department of Biology-College of

Scince- Tikrit University/Iraq

Published

2020-07-30

How to Cite

Yaseen Khalaf Mohammed1 , Ayad Hameed Ibrahim2 , Aziz Khalid Hameed3. (2020). Histological Evaluation of the Effect of Metronidazolemedicine on the Brain Tissue in Adult Female White Rats. Indian Journal of Forensic Medicine & Toxicology, 14(3), 2421-2427. https://doi.org/10.37506/ijfmt.v14i3.10799