Study the Glucose Transport, Angiogenesis and Apoptosis Behavioral through Chemotherapy Treatment According to Receptors Status in Women with Breast Cancer

Authors

  • Hamzah H. Kzar1 , Moshtak A. wtwt2 , Moaed E. Al-Gazally3

Keywords:

Breast cancer, glucose transport, angiogenesis, apoptosis.

Abstract

Background: Glucose transporting into cells, angiogenesis, and apoptosis are the main factors that inducing

the progression of many types of cancers including breast cancer. BC progression was seen as a multi-step

process involving progressive changes from normal to hyperplasia with and without atypia, carcinoma in

situ, invasive carcinoma, and metastasis.

Aim: Assessment the role of glucose transport-1 (GLUT-1), vascular endothelial growth factor (VEGF),

and cluster of differentiation factor(CD44) as a glucose transporting into cells, angiogenesis, and apoptotic

factors in women with BC whom receiving chemotherapy.

Method and Subjects: 120 women with BC included in this study as a patients group as well as 120

apparently healthy women as control. The women with BC is divided into sub-groups depending on

chemotherapy treatment status. GLUT-1, VEGF, and CD44 were investigated by ELISA method.

Results: This study suggested that highly significant differences in the mean and standard division of GLUT?1

and VEGF in all cases of women with BC compare to control group (P-Value< 0.05). The levels of GLUT?1

was highly significant difference between two subgroup have Her?2 positive and negative (p < 0.001), and

the levels of VEGF, and CD44 in patients subgroups were significant (p< 0.05).

Conclusion: The following up of the progression and responding to chemotherapy treatment may be more

easy by estimation the glucose transporting, angiogenesis, and apoptotic markers in women with BC.

Author Biography

Hamzah H. Kzar1 , Moshtak A. wtwt2 , Moaed E. Al-Gazally3

1 Lecturer, Department of Chemistry, Veterinary Medicine Collage, Al-Qasim Green University, Iraq, 2Professor,

College of Medicine, University of Babylon, Iraq, 3 Prof. Dr., College of Medicine, Babylon University, Work Now

at University of Al-Ameed, Iraq

Published

2020-07-30

How to Cite

Hamzah H. Kzar1 , Moshtak A. wtwt2 , Moaed E. Al-Gazally3. (2020). Study the Glucose Transport, Angiogenesis and Apoptosis Behavioral through Chemotherapy Treatment According to Receptors Status in Women with Breast Cancer. Indian Journal of Forensic Medicine & Toxicology, 14(3), 2555-2559. Retrieved from http://medicopublication.com/index.php/ijfmt/article/view/10822