Study Effects of Nigella Sativa Seeds Oil in Some Physiological Parameters in Experimental Heart Failure Induced by Ivabradine in Male Rats

Abstract

Aim of this study was to investigate the effects of Nigella Sativa Seeds oil In some physiological parameters

against heart failure Induced By Ivabradine in rats .A total of 60 male rats were used in this experiment, the

rats were divided into three groups: control rats (n = 20); IBD (n = 20); IBD+ N. sativa oil (n = 20). The

first group (G1) was a control group. The second group (G2) was given 10 mg/kg of IBD, while the third

group (G3) was injected with 10 mg/kgIBD + oral dosage of 2.5 mg/kg N. sativa oil for three months., after

three months, the blood was withdrawn from the heart. to measure the concentration of ANP, BNP, NE,

A-II, ALDO, ACE, MDA, SOD, TNF-? and IL-6 the Results revels that Levels of BNP, NE, MDA, IL-6

and TNF-?. were significantly increasead in G2 rats, with no significant difference was observed in ANP

in rats in G2 compared to G1 rats . The level of ACE, A-II, SOD and ALDO in G2 rats had significantly

decreased compared to that observed in G1 rats, oral administration of Nigella Sativa seeds oil (G3) showed

no significant difference inANP, BNP, NE, A-II, ALDO, ACE, MDA, SOD, TNF-? and IL-6 compared with

G1 group.