Relation of Endothelin-1 and Malondialdehyde with Pre-eclampsia in Pregnant Women
Keywords:Endothelin-1; MDA; pre-eclampsia; Pregnancy
A case-control study was conducted in Kirkuk city in Kirkuk general hospital from first of March 2018 and
to end of September 2018 to evaluate the role of endothelin-1 and malondialdehyde in pathogenesis of pre
eclampsia in pregnant women. The study included 30 pregnant women with preeclampsia, patients were
defined and divided according to the National High Blood Pressure Education Program Working Group on
High Blood Pressure in Pregnancy. A control group of 30 healthy normotensive pregnant females was also
included. All comparison groups were matched for mother’s age, parity, and gestational age at the time of
enrollment and blood collection. Three ml of blood was collected by vein puncture, blood samples were
placed into sterile test tubes and left for 30 minutes at 37 °C then were centrifuged at 3000 rpm for 15
minutes then the clot was removed and the obtained sera were then aspirated using automatic micropipette
and transferred into clean test tubes and stored in deep freeze at -20°C for determination of endothelin-1 and
malondialdehyde by usingELISA technique. The study showed that the highest mean level of endothelin-1
was found in pregnant women with pre-eclampsia(13.15±2.81 pg/ml) and the lowest mean was in the
control group (0.41±0.31 pg/ml). The result was highly significant (P<0.01). The study showed that the
highest mean level of MDA was found in pregnant women with pre-eclampsia (6.75±2.94 nmol/ml) and
the lowest mean was recorded in the control group (3.85±1.29 nmol/ml). The result was highly significant
(P<0.01). The current study showed that the mean age of patients enrolled in the study was 33.5 years, the
highest mean of endothelin-1 in HD patients was recorded within the age group 20-29 year of pregnant
women with pre-eclampsia. Although the results was non-significant. The study showed positive correlation
between endothelin-1 and MDA levels pregnant women with pre-eclampsia. It was concluded that serum
endothelin-1 and MDA levels were highly correlated with pregnant women with pre-eclampsia
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