Correlation of Toxoplasmosis Seroprevalence and Serum Level of Interleukin-10 in Iraqi Breast Cancer Women

Authors

  • Maysoon Abdul-zahra Merdaw1 , Zeina Anwar Jaffar2 , Zahraa Mohammed Ali3 , Heba Hashim Khalil4

DOI:

https://doi.org/10.37506/ijfmt.v14i3.11837

Keywords:

Breast cancer, ELISA, interleukine-10, Iraq, Toxoplasma gondii

Abstract

Background: Toxoplasmosis is regarded as one of the most important global life-threatening diseases in
immune-compromised people. The intracellular protozoon Toxoplasma gondii is the causative pathogen of
toxoplasmosis. Aim of this study is to investigate the possible association between T. gondii infection and
breast cancer (BC) in Iraqi women, also to assess the effect of T. gondii on interleukin 10 (IL-10) of the
immune response. By ELISA method, blood samples from 81 women with breast cancer and 60 apparently
healthy women have been examined for presence of anti-toxoplasma antibodies, also the levels of serum
IL-10 were estimated in these subjects. Results showed that women with BC had the highest prevalence
rate of toxoplasmosis. The anti- T.gondii antibodies was 38.27% for IgG and 4.93% for IgM, while in
the control group it was 26.66% and 0.0% respectively, with no significant difference for IgG (P =0.148)
and IgM (P = 0.081). A highly significant difference was found in the level of IL-10 between BC women
with toxoplasmosis (10.24%) and BC women without toxoplasmosis (3.6%). These findings suggest that
incidence rate of T. gondii infection is higher in breast cancer women and higher level of IL-10 than their
cross-matched control subjects. Therefore, we recommend the inclusion of a screening test for toxoplasmosis
and the level of IL-10 in BC patients as in their routine workup.

Author Biography

Maysoon Abdul-zahra Merdaw1 , Zeina Anwar Jaffar2 , Zahraa Mohammed Ali3 , Heba Hashim Khalil4

1
Assistant Professor , Department of Clinical Laboratory Sciences, College of Pharmacy, University of Baghdad,
Baghdad, Iraq, 2
Lecturer ,Department of Medical Laboratory Technology, College of Health and Medical
technique, Middle Technical University, Baghdad, Iraq, 3Lecturer , Department of Clinical Laboratory Sciences,
College of Pharmacy, University of Baghdad, Baghdad, Iraq, 4Pharmacist , Department of Clinical Laboratory
Sciences, College of Pharmacy, University of Baghdad, Baghdad, Iraq

Published

2020-10-29

How to Cite

Maysoon Abdul-zahra Merdaw1 , Zeina Anwar Jaffar2 , Zahraa Mohammed Ali3 , Heba Hashim Khalil4. (2020). Correlation of Toxoplasmosis Seroprevalence and Serum Level of Interleukin-10 in Iraqi Breast Cancer Women. Indian Journal of Forensic Medicine & Toxicology, 14(3), 1973-1978. https://doi.org/10.37506/ijfmt.v14i3.11837