Clinical Evaluation of Local Drug Delivery of Chlorhexidine and Ornidazole in the Treatment of Gingivitis as an Adjunct to Scaling and Root Planing

Authors

  • Roopalakshmi Narayanan1 , Munivenkatappa Lakshmaiah Venkatesh Prabhuji2 , Shaeesta Khaleelahmed Bhavikatti3 , Shahabe A. Saquib4 , Rashmi Paramashivaiah, Mohmed Isaqali Karobari6 , Farheen Ustad7

DOI:

https://doi.org/10.37506/ijfmt.v14i4.12322

Keywords:

inflammation, gingivitis, chlorhexidine, ornidazole

Abstract

Background: Local drug delivery to gingival sulcus avoids adverse effects seen with systemic therapy and
there is very little information to substantiate the additive effect of the drugs, the current study makes an
attempt in same regard.
Aim: The objective of this study was to compare the local application of ornidazole and chlorhexidine gel
(ClorniTM gel) as an adjunct to scaling and polishing, with scaling and polishing alone.
Materials and methods: 33 patients meeting inclusion criteria were randomly allocated to treatment
groups by computerized randomly selection method. Indices were recorded at baseline at their first visit.
Supragingival and subgingival scaling and polishing was performed using hand and ultrasonic instruments.
The patients were evaluated clinically by using the gingival index, plaque index and modified sulcus bleeding
index. On test side, ClorniTM gel was applied subgingivally after nonsurgical periodontal therapy. On the
control side, no intervention was done following subgingival scaling and polishing. Patients were recalled
at 7th day for subsequent administration of gel on the same site and followed up at 21st day and 3 months to
compare the gingival condition by using the indices.
Results: All subjects showed significant improvement over 3 months recall period, irrespective of test or
controls. Statistical significance (p? 0.05) was observed at 7 days and 21 days for test group for the gingival
index and at 21 days for the plaque index and modified sulcus bleeding index.
Conclusion: The topical gel when used as an adjunct to scaling and polishing had significant results.

Author Biography

  • Roopalakshmi Narayanan1 , Munivenkatappa Lakshmaiah Venkatesh Prabhuji2 , Shaeesta Khaleelahmed Bhavikatti3 , Shahabe A. Saquib4 , Rashmi Paramashivaiah, Mohmed Isaqali Karobari6 , Farheen Ustad7

    1Clinical Head, Challa Hospital, Ameerpet, Hyderabad, 2Professor and Head, Department of Periodontics,
    Krishnadevaraya College of Dental Sciences and Hospital, India, 3
    Assistant Professor, Division of Periodontics
    and Community Dental Sciences, College of Dentistry, King Khalid University, 4Assistant Professor, Division of
    Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, 5
    Reader, Department
    of Periodontics, Krishnadevaraya College of Dental Sciences and Hospital, Bangalore, India, 6Postgraduate,
    Conservative unit, School of Dental Sciences, Universiti Sains Malaysia (USM), 7
    Associate Professor, Department
    of Oral and Maxillofacial Dentistry, Majmah University, K.S.A.

Downloads

Published

2020-10-29

How to Cite

Clinical Evaluation of Local Drug Delivery of Chlorhexidine and Ornidazole in the Treatment of Gingivitis as an Adjunct to Scaling and Root Planing. (2020). Indian Journal of Forensic Medicine & Toxicology, 14(4), 4346-4353. https://doi.org/10.37506/ijfmt.v14i4.12322