Coenzyme Q10 in the Follicular Fluid and Its Relation to Oocyte Maturity, Fertilization Rate, Embryo Grading, and Pregnancy Rate
Keywords:CoQ10, pregnant rate, oocyte maturity, fertilization rate, embryo grading.
Background: Infertility was define as; a disease characterized by the failure to establish a clinical pregnancy
after 12 months of regular unprotected sexual intercourse, or due to an impairment of a person’s capacity
to reproduce, either as an individual or with his/her partner. According to the latest definition by the
international glossary on infertility and fertility care, regular sexual intercourse is an important determinant
for the occurrence of pregnancy.
Aim of the study: To assess the relation between Coenzyme Q10 level in the follicular fluid with oocyte
maturity, fertilization rate, embryo grading, and pregnancy rate
Patients and method: A prospective cross sectional study conducted at the High Institute for Infertility
Diagnosis and Assisted Reproductive Technologies / Al-Nahrain University and in fertility center at AlSadr general hospital during the period from December 2019 to August 2020. Sixty infertile couples were
enrolled in this study; all underwent ICSI cycles
Results: Mean level of Co Q10 in Grade III and IV (0.387 ± 0.54) than that in Grade I and II (0.539 ± 0.65),
CoQ10 total in pregnant were 0.79 ± 0.63 and in non-pregnant were 0.381 ± 0.2, A threshold of 0.27 of
CoQ10 had a sensitivity of 80.0% and specificity of 67.0 %, PPV was (88.0%), NPV (45%) and accuracy
was (74%). ROC curve of CoQ10 for pregnancy prediction
Conclusion: Significant decrease of Co Q10 between in Grade III and IV than that in Grade I and II. CoQ10
total were increase in pregnant women than non-pregnant.
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