Review: Cancer Cells Resistance Strategies

Authors

  • Ali Faris Hassan1 , Nada Naji Al-Shawi 1, Mahmood Kahtan Salih1 , Pharmacsit Rusul Mohammed Hassan Ali 2 , Biologist Omar Faris Hasan3

DOI:

https://doi.org/10.37506/ijfmt.v15i1.13512

Keywords:

cancer, resistance, inactivation, apoptosis, DNA damage

Abstract

Cancer, which is the most important health problem, develops the ability to resistant traditional medications
this leads to increase efforts to develop new cancer medication protocols. In this review, the chemotherapy
resistance could be due to several mechanisms. These mechanisms involve either inactivation by two
important phases, phase I which involve oxidation, reduction and hydrolysis or phase II which involve
conjugation wi, alteration of the target site which decrease either activation of anticancer prodrug and/or
decrease its influx to cancer cells. Other mechanisms for chemotherapy resistance return to the repairing
of cancer cell DNA, modulation of efflux for drug, inactivation of apoptosis, besides how the role of
heterogeneity of tumor cells in drug resistance. All of these strategies obligated the oncologist to use a
combination of chemotherapy medication to overcome or avoid resistances to treatments.

Author Biography

Ali Faris Hassan1 , Nada Naji Al-Shawi 1, Mahmood Kahtan Salih1 , Pharmacsit Rusul Mohammed Hassan Ali 2 , Biologist Omar Faris Hasan3

1
Scholar Researcher, Department of Pharmacology and Toxicology - College of Pharmacy- University of Baghdad,
Iraq, 2
Scholar researcher, Department of Pharmaceutical Chemistry - College of Pharmacy- University of
Baghdad, Iraq, 3Scholar researcher, Department of Basic Sciences-College of Medicine-Ibn Sina University of
Medical and Pharmaceutical Sciences, Iraq

Published

2020-12-31

How to Cite

Ali Faris Hassan1 , Nada Naji Al-Shawi 1, Mahmood Kahtan Salih1 , Pharmacsit Rusul Mohammed Hassan Ali 2 , Biologist Omar Faris Hasan3. (2020). Review: Cancer Cells Resistance Strategies . Indian Journal of Forensic Medicine & Toxicology, 15(1), 791-797. https://doi.org/10.37506/ijfmt.v15i1.13512

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