Efficacy of Hyaluronic Acid in Patients with Osteoarthritis of The Knee
Keywords:Osteoarthritis, hyaluronic acid , hyaluronate physiochemical functions, extracellular matrix, glycosaminoglycan , Knee Intra-articular injection.
Osteoarthritis (OA) of the knee is the most common chronic degenerative joint disease characterized by pain,
stiffness, swelling and progressive functional limitation in elderly. Non-surgical management modalities
like physical therapy, lifestyle modification and oral non-steroidal anti-inflammatory drugs, are often
ineffective or do not alleviate symptoms adequately. Intra-articular corticosteroid (CS) and hyaluronic acid
(HA) injections have been used for long to alleviate the symptoms of knee OA. viscosupplementation has
been used as a therapeutic modality for the management of knee OA. The principle of viscosupplementation
is based on the physiological properties of the hyaluronic acid (HA) in the synovial joint which helps tissue
lubricate, cushion and reduce pain in the joint.
Study diagnosed forty patient of knee Osteoarthritis for both gender with age (45-70 years) and observed
change and effectiveness to pre-and post of HA injection, All patients diagnosed by Orthopedists and
Rheumatologists whose used X-rays were graded as stage I, II and III according to Kellgren and Lawrence
All the measurements were used at the time of enrollment in the study before any injection and then measured
again at the end of three months by using Western Ontario and McMaster University Osteoarthritis Index
All the patients before therapy were having minimum score of 72.4 & 9.045 for Mean and Standard Deviation
respectively while after the therapy there score reduced to 36.2 & 4.783.
The results show improvement significant during four month under study and the effect peaks at around
8–12 weeks following administration, This supports the potential use of intra-articular HA as an effective
long therapeutic option for patients with OA of the knee.
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