Biological Activity Investigation of Phytocomponents in Mangosteen (Garcinia mangostana L.): In Silico Study

Authors

  • Arif Nur Muhammad Ansori1 , Raden Joko Kuncoroningrat Susilo2 , Suhailah Hayaza2

DOI:

https://doi.org/10.37506/ijfmt.v15i1.13522

Keywords:

Biological activity, Garcinia mangostana L., in silico.

Abstract

Indonesia has abundant medicinal plants, which have been historically used by the population in treating
diseases for generations. Traditional Indonesian medicine and the medicinal plants used could lead to the
discovery of novel drugs. The mangosteen or Garcinia mangostana L. is a well-known medicinal plant
that has been used to treat various diseases worldwide. The pharmacological activities and phytochemical
composition of the whole plant of mangosteen have been investigated and identified by scientists in recent
decades. Therefore, this study aims to generate the prediction of the biological activity of phytocompotents
in mangosteen. In this study, we extracted 18 phyocomponents of mangosteen from PubChem, an open
chemistry database at the National Institutes of Health (NIH), USA. Then, we predicted the pharmacokinetic
properties and druglike nature of the phytocomponents using the SwissADME web server, Swiss Institute
of Bioinformatics, Swiss. Furthermore, PASS (Prediction of Activity Spectra for Substances) web resource
has been employed as a strong potential tool to predict the biological activity. In summary, we revealed the
biological activity of 18 phytocomponents of the mangosteen. However, further trials, such as in vitro and
in vivo evaluation, are needed to prove the validity of these findings.

Author Biography

Arif Nur Muhammad Ansori1 , Raden Joko Kuncoroningrat Susilo2 , Suhailah Hayaza2

1Doctoral Student, Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas
Airlangga, Surabaya, Indonesia, 2Doctoral Student, Doctoral Program in Mathematics and Natural Sciences,
Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia

Published

2020-12-31

How to Cite

Arif Nur Muhammad Ansori1 , Raden Joko Kuncoroningrat Susilo2 , Suhailah Hayaza2. (2020). Biological Activity Investigation of Phytocomponents in Mangosteen (Garcinia mangostana L.): In Silico Study. Indian Journal of Forensic Medicine & Toxicology, 15(1), 847-851. https://doi.org/10.37506/ijfmt.v15i1.13522