Biological Activity Investigation of Phytocomponents in Mangosteen (Garcinia mangostana L.): In Silico Study
Keywords:Biological activity, Garcinia mangostana L., in silico.
Indonesia has abundant medicinal plants, which have been historically used by the population in treating
diseases for generations. Traditional Indonesian medicine and the medicinal plants used could lead to the
discovery of novel drugs. The mangosteen or Garcinia mangostana L. is a well-known medicinal plant
that has been used to treat various diseases worldwide. The pharmacological activities and phytochemical
composition of the whole plant of mangosteen have been investigated and identified by scientists in recent
decades. Therefore, this study aims to generate the prediction of the biological activity of phytocompotents
in mangosteen. In this study, we extracted 18 phyocomponents of mangosteen from PubChem, an open
chemistry database at the National Institutes of Health (NIH), USA. Then, we predicted the pharmacokinetic
properties and druglike nature of the phytocomponents using the SwissADME web server, Swiss Institute
of Bioinformatics, Swiss. Furthermore, PASS (Prediction of Activity Spectra for Substances) web resource
has been employed as a strong potential tool to predict the biological activity. In summary, we revealed the
biological activity of 18 phytocomponents of the mangosteen. However, further trials, such as in vitro and
in vivo evaluation, are needed to prove the validity of these findings.
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