Investigate the therapeutic effect of autologous adipose-derived stem cells (ADSCs) on ischemic renal failure in dogs.

Authors

  • Bassim K .Khashjoori1 , M. S. Ghaji1 , Omar Tariq Hammoodi2 , Majid A. Alkhilani2 , Ali. A. Ajeel 3 , Lubna Muslim Abdulkareem4 , Abdullah Qassim Mohammad4

DOI:

https://doi.org/10.37506/ijfmt.v15i1.13526

Keywords:

dog, ischemic renal failure, autologous adipose-derived stem cells

Abstract

Background/ aim: The kidney excretes waste materials and regulates important metabolic functions, and
renal disorders constitute a significant medical problem and can result in fatalities. In the present study,
mesenchymal stem cells derived from canine adipose tissue were isolated and evaluated for their ability to
improve renal function in a canine model of ischemic renal failure. Materials and Methods: The canine
ischemic renal failure model was developed by a traumatic occlusion of the renal artery in 10 dogs. ASCs
were administered directly into the renal artery following ischemic renal failure induction. Blood analysis
and histological parameters were analyzed. Results: The group treated with ASCs had decreased blood urea
nitrogen and creatinine levels, and showed an improving histological manifestation. ASCs were detected
around the tubules of these kidneys at the histological level. Conclusion: our findings suggest that ASCs
could be an alternative therapeutic agent for canine ischemic renal failure.

Author Biography

Bassim K .Khashjoori1 , M. S. Ghaji1 , Omar Tariq Hammoodi2 , Majid A. Alkhilani2 , Ali. A. Ajeel 3 , Lubna Muslim Abdulkareem4 , Abdullah Qassim Mohammad4

1 Tutor, Department of Surgery and obstetric College of Veterinary Medicine, Basrah University, Iraq,
2
Tutor, Department of Surgery and obstetric, College of Veterinary Medicine, University of Fallujah, Iraq,
3Assistant Professor, Department of Surgery and Obstetric, College of Veterinary Medicine, Al-Muthanna
University, Iraq,4
Resident, College of Veterinary Medicine, Basrah University, Iraq

Published

2020-12-31

How to Cite

Bassim K .Khashjoori1 , M. S. Ghaji1 , Omar Tariq Hammoodi2 , Majid A. Alkhilani2 , Ali. A. Ajeel 3 , Lubna Muslim Abdulkareem4 , Abdullah Qassim Mohammad4. (2020). Investigate the therapeutic effect of autologous adipose-derived stem cells (ADSCs) on ischemic renal failure in dogs. Indian Journal of Forensic Medicine & Toxicology, 15(1), 871-878. https://doi.org/10.37506/ijfmt.v15i1.13526