Investigate the therapeutic effect of autologous adipose-derived stem cells (ADSCs) on ischemic renal failure in dogs.
Keywords:dog, ischemic renal failure, autologous adipose-derived stem cells
Background/ aim: The kidney excretes waste materials and regulates important metabolic functions, and
renal disorders constitute a significant medical problem and can result in fatalities. In the present study,
mesenchymal stem cells derived from canine adipose tissue were isolated and evaluated for their ability to
improve renal function in a canine model of ischemic renal failure. Materials and Methods: The canine
ischemic renal failure model was developed by a traumatic occlusion of the renal artery in 10 dogs. ASCs
were administered directly into the renal artery following ischemic renal failure induction. Blood analysis
and histological parameters were analyzed. Results: The group treated with ASCs had decreased blood urea
nitrogen and creatinine levels, and showed an improving histological manifestation. ASCs were detected
around the tubules of these kidneys at the histological level. Conclusion: our findings suggest that ASCs
could be an alternative therapeutic agent for canine ischemic renal failure.
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