Overview of the Content of Bisphenol A in the Amniotic Fluid of Pregnant Women And Its Adverse Health Outcomes
Keywords:amniotic fluid; Bisphenol A, pregnancy; adverse health outcomes;
Background: This review represents a critical and constructive analysis of literature in the content of
Bisphenol A in amniotic fluid of pregnant women and its adverse health outcomes. The review is generated
through summary, classification, analysis and comparison of already existing material and researches on
Methods : Databases as Scopus, PubMed, Medline, Web of Science, Global Health, were used to extract
data for the review. Search terms like “Bisphenol A”, “pregnancy”, “amniotic fluid”, “endocrine disruptors”
were used. Out of 200 research articles screened, 70 most relevant studies are included in this review.
Conclusions: This review highlights the correlation between Bisphenol A and its endocrine disrupting
potential, impacting especially fragile categories as pregnant women and their fetuses through its
toxicokinetic features and its metabolites. Thus, BPA distorts important physiological processes necessary
for fetal development and disease progression later in life.
We can conclude that human exposure to BPA, as one of the leading environmental contaminants, represents
a major global issue and its adverse health outcomes can be debilitating for human health. Further research
on field considering BPA distribution, varying exposure rates, racial disparities, inter-species differences and
EDCs cumulative effects, should be conducted. Finding safer alternatives for replacing BPA in market must
remain a priority.
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