Correlation between CD4 T lymphocyte and Candida Species Counts In Oral Candidiasis Patients with HIV / AIDS
Keywords:Candida sp, CD4 T lymphocytes, HIV / AIDS, oral candidiasis
Background: Candida sp. is the most common opportunistic pathogen found during the development of
Human immunodeficiency virus (HIV) & Acquired immune deficiency syndrome (AIDS) disease. The
clinical severity of oral candidiasis and the prevalence profile of Candida species reflect immunological
changes in HIV / AIDS patients. Objective: Evaluating the relationship between CD4 T lymphocyte cells
counts and the number of Candida species. Methods: A cross-sectional analytical study was carried out
at Dr. Soetomo, Surabaya, Indonesia. For identification of Candida species, culture was carried out on
Chromagar media followed by culture with vitek 2. Results: There were 114 study subjects who were
divided into three groups based on the number of CD4 T lymphocyte cells, with 158 isolates of Candida
species growing in culture. The highest number of Candida species was Candida albicans with a total of 107
isolates (67.7%). Candida non-albicans were 51 isolates (32.3%). Statistical test results showed a significant
correlation between the number of CD4 T lymphocyte cells and the number of Candida species (p <0.001).
Conclusion: The decrease in CD4 lymphocyte cell counts is influenced by various types of Candida sp. in
oral candidiasis patients.
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