Correlation between CD4 T lymphocyte and Candida Species Counts In Oral Candidiasis Patients with HIV / AIDS

Authors

  • Dwi Murtiastutik1 , Cita Rosita Sigit Prakoswa2 , Indah Setyawati Tantular 3, Evy Ervianti1 , Afif Nurul Hidayati4 , Muhammad Yulianto Listiawan4

DOI:

https://doi.org/10.37506/ijfmt.v15i1.13548

Keywords:

Candida sp, CD4 T lymphocytes, HIV / AIDS, oral candidiasis

Abstract

Background: Candida sp. is the most common opportunistic pathogen found during the development of
Human immunodeficiency virus (HIV) & Acquired immune deficiency syndrome (AIDS) disease. The
clinical severity of oral candidiasis and the prevalence profile of Candida species reflect immunological
changes in HIV / AIDS patients. Objective: Evaluating the relationship between CD4 T lymphocyte cells
counts and the number of Candida species. Methods: A cross-sectional analytical study was carried out
at Dr. Soetomo, Surabaya, Indonesia. For identification of Candida species, culture was carried out on
Chromagar media followed by culture with vitek 2. Results: There were 114 study subjects who were
divided into three groups based on the number of CD4 T lymphocyte cells, with 158 isolates of Candida
species growing in culture. The highest number of Candida species was Candida albicans with a total of 107
isolates (67.7%). Candida non-albicans were 51 isolates (32.3%). Statistical test results showed a significant
correlation between the number of CD4 T lymphocyte cells and the number of Candida species (p <0.001).
Conclusion: The decrease in CD4 lymphocyte cell counts is influenced by various types of Candida sp. in
oral candidiasis patients.

Author Biography

Dwi Murtiastutik1 , Cita Rosita Sigit Prakoswa2 , Indah Setyawati Tantular 3, Evy Ervianti1 , Afif Nurul Hidayati4 , Muhammad Yulianto Listiawan4

1Lecture, 2Professor, Department of Dermatology and Venereology, Faculty of Medicine, Universitas AirlanggaDr. Soetomo General Hospital, Surabaya, Indonesia, 3Professor, Department of Parasitology, Faculty of Medicine,
Universitas Airlangga, Surabaya, Indonesia, 4Associate Professor, Department of Dermatology and Venereology,
Faculty of Medicine, Universitas Airlangga-Dr. Soetomo General Hospital, Surabaya, Indonesia

Published

2020-12-31

How to Cite

Dwi Murtiastutik1 , Cita Rosita Sigit Prakoswa2 , Indah Setyawati Tantular 3, Evy Ervianti1 , Afif Nurul Hidayati4 , Muhammad Yulianto Listiawan4. (2020). Correlation between CD4 T lymphocyte and Candida Species Counts In Oral Candidiasis Patients with HIV / AIDS. Indian Journal of Forensic Medicine & Toxicology, 15(1), 1013-1020. https://doi.org/10.37506/ijfmt.v15i1.13548