Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole
Keywords:Antifungal activity, Candida albicans, Candida non-albicans, EGCG, Fluconazole, HIV/AIDS, Oral candidiasis
Background: Oral Candidiasis (OC) still mainly oportunistic infection problem in HIV/AIDS Patients.
Due to increasing report of fluconazole resistant as common antifungal drugs nowadays, there have been
many studies focusing on natural substances and its antifungal properties. In this study, a form of green tea
extract, named Epigallocathechingallate (EGCG) 1,25% were examined for their in vitro antifungal activity against Candida sp in comparison to fluconazole (2 mg/ml) as standard antifungal agents.Objective:
To evaluate the antifungal activity of EGCG in compare with fluconazole against Candida isolates taken
from HIV / AIDS patients with OC. Methods: Fourty Candida sp. isolates taken from HIV / AIDS patients
with OC in the Outpatient Unit and Inpatient Installation of the Infectious Disease Intermediate Care Unit
(UPIPI) Dr. Soetomo, Surabaya. Antifungal activity were evaluated by using microdilution tests. Results:
The microdilution test revealed the MIC of EGCG for all Candida sp. was 0.625%, while the MIC of
fluconazole was 100% for all Candida sp. There was significant difference (p <0.05) between the MIC
values for Candida sp. by fluconazole and EGCG. The MFC values of EGCG was 50%, while value of
fluconazole MFC was 100%. Conclusion: Antifungal activity of EGCG with fungistatic and fungicidal
effect is better than fluconazole.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions