Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole

Authors

  • Dwi Murtiastutik1 , Cita Rosita Sigit Prakoswa2 , Indah Setyawati Tantular3 , Yusuf Wibisono1 , Afif Nurul Hidayati4 , Sawitri1 , Muhammad Yulianto Listiawan4

DOI:

https://doi.org/10.37506/ijfmt.v15i1.13549

Keywords:

Antifungal activity, Candida albicans, Candida non-albicans, EGCG, Fluconazole, HIV/AIDS, Oral candidiasis

Abstract

Background: Oral Candidiasis (OC) still mainly oportunistic infection problem in HIV/AIDS Patients.
Due to increasing report of fluconazole resistant as common antifungal drugs nowadays, there have been
many studies focusing on natural substances and its antifungal properties. In this study, a form of green tea
extract, named Epigallocathechingallate (EGCG) 1,25% were examined for their in vitro antifungal activity against Candida sp in comparison to fluconazole (2 mg/ml) as standard antifungal agents.Objective:
To evaluate the antifungal activity of EGCG in compare with fluconazole against Candida isolates taken
from HIV / AIDS patients with OC. Methods: Fourty Candida sp. isolates taken from HIV / AIDS patients
with OC in the Outpatient Unit and Inpatient Installation of the Infectious Disease Intermediate Care Unit
(UPIPI) Dr. Soetomo, Surabaya. Antifungal activity were evaluated by using microdilution tests. Results:
The microdilution test revealed the MIC of EGCG for all Candida sp. was 0.625%, while the MIC of
fluconazole was 100% for all Candida sp. There was significant difference (p <0.05) between the MIC
values for Candida sp. by fluconazole and EGCG. The MFC values of EGCG was 50%, while value of
fluconazole MFC was 100%. Conclusion: Antifungal activity of EGCG with fungistatic and fungicidal
effect is better than fluconazole.

Author Biography

Dwi Murtiastutik1 , Cita Rosita Sigit Prakoswa2 , Indah Setyawati Tantular3 , Yusuf Wibisono1 , Afif Nurul Hidayati4 , Sawitri1 , Muhammad Yulianto Listiawan4

1Lecture, 2Professor, Department of Dermatology and Venereology, Faculty of Medicine, Universitas AirlanggaDr. Soetomo General Hospital, Surabaya, Indonesia, 3Professor, Department of Parasitology, Faculty of Medicine,
Universitas Airlangga, Surabaya, Indonesia, 4Associate Professor, Department of Dermatology and Venereology,
Faculty of Medicine, Universitas Airlangga-Dr. Soetomo General Hospital, Surabaya, Indonesia

Published

2020-12-31

How to Cite

Dwi Murtiastutik1 , Cita Rosita Sigit Prakoswa2 , Indah Setyawati Tantular3 , Yusuf Wibisono1 , Afif Nurul Hidayati4 , Sawitri1 , Muhammad Yulianto Listiawan4. (2020). Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole . Indian Journal of Forensic Medicine & Toxicology, 15(1), 1021-1026. https://doi.org/10.37506/ijfmt.v15i1.13549