Impact of Bone Marrow Mesenchymal Stem Cells on Different Body Organs of Albino Rats Exposed To Cadmium Chloride Toxicity: A Systematic Review
Keywords:Cadmium chloride; bone marrow stem cells; rats; systematic review.
Background and Objective: Cadmium chloride (Cd cl2) is a highly toxic heavy metal that causes severe
degenerative effects to different body organs. Bone marrow mesenchymal stem cells (BMMSCs) may have
a protective effect upon CdCl2 induced structural and functional changes in the rat’s organs. This systematic
review aimed to test the regenerative effects of bone marrow?derived mesenchymal stem cells on different
body organs of albino rats exposed to cadmium chloride toxicity.
Methods: Experimental animal studies were identified by the following electronic databases: PubMed,
Scopus, Ovid Medline, KoreaMed, Google Scholar, Latin American and Caribbean Health Sciences
Literature (LILACS) and Central Cochrane Library. The literature search was done from January 2010 to
Conclusion: From the selected articles, using stem cell therapy enhances the regeneration process in CdCl2
toxicity of different body organs.
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