Neutrophil Lymphocyte Ratio and Acid-Fast Bacilli in Tuberculosis

Authors

  • Haerani Harun1 , Muhammad Nasir2 , Sumarni3, Rosa Dwi Wahyuni1 , Dita aridhatamy4 , Nur Aulia Pratiwi4

DOI:

https://doi.org/10.37506/ijfmt.v15i1.13561

Keywords:

Tuberculosis, Acid-Fast Bacilli, Neutrophil, Lymphocyte, Neutrophil Lymphocyte Ratio

Abstract

Background: Tuberculosis (TB) is one of the top 10 causes of death in the world and the most common
cause of death with single infectious agent. The neutrophil-lymphocyte ratio is a cheap and fast marker of
inflammation that has been widely studied in TB. The aimed of this study was to investigate Neutrophillymphocyte ratio (NLR) in TB with positive Acid-Fast Bacilli (AFB) and negative AFB. Methods: This
was a retrospective study that included TB patients data from the medical records in two hospitals in Palu,
Indonesia. A total of 150 TB patients were involved in this study consisting with positive and negative AFB
TB suspect. Neutrophil, lymphocyte and NLR data were compared with the Mann-Whitney test. Results:
The study shows a significant difference of neutrophils and lymphocytes percentage between positive AFB
TB patients (80 subjects, 53.3%) and negative AFB TB patients (70 subjects, 46.7%) with (p < 0.001) as well
as NLR (p < 0.001). The percentage of Neutrophils was significantly higher in positive AFB TB compared
to negative AFB tuberculosis (81.18 ± 8.52 vs. 55.02 ± 9.80), lymphocyte percentage were found to be
significantly lower in positive AFB TB compared with negative AFB TB (12.72 ± 7.51 vs 28.69 ± 12.01).
Additionally, NLR were significantly higher in positive AFB TB compared with negative AFB TB (10.20 ±
9.53 vs 2.47 ± 1.56). Conclusion: There is a significant increase in the number of neutrophils, a decrease in
lymphocytes and an increase in NLR among positive AFB TB compared with negative AFB TB.

Author Biography

Haerani Harun1 , Muhammad Nasir2 , Sumarni3, Rosa Dwi Wahyuni1 , Dita aridhatamy4 , Nur Aulia Pratiwi4

1Lecture, Department of Clinical Pathology, Faculty of Medicine, Tadulako University, Palu 94148, Indonesia,
2
Lecture, Department of Tropical Infection and Traumatology, Faculty of Medicine, Tadulako University, Palu
94148, Indonesia, 3Lecture, Departement of Medical Nutrition, Faculty of Medicine, Tadulako University, Palu
94148, Indonesia, 4Student of Medical Education Program, Faculty of Medicine, Tadulako University, Palu 94148,
Indonesia

Published

2020-12-31

How to Cite

Haerani Harun1 , Muhammad Nasir2 , Sumarni3, Rosa Dwi Wahyuni1 , Dita aridhatamy4 , Nur Aulia Pratiwi4. (2020). Neutrophil Lymphocyte Ratio and Acid-Fast Bacilli in Tuberculosis . Indian Journal of Forensic Medicine & Toxicology, 15(1), 1091-1096. https://doi.org/10.37506/ijfmt.v15i1.13561