Relationship Between High Sensitivity TNF-? WITH clinical outcome During Admission In Acute Ischemic Stroke

Authors

  • Mohammad Saiful Ardhi1 , Mohammad Saiful Islam1

DOI:

https://doi.org/10.37506/ijfmt.v15i1.13595

Keywords:

TNF-?, HS TNF-?, clinical outcome , acute ischemic stroke.

Abstract

Background : Tumor necrosis factor alpha (TNF-?), together with other pro-inflammatory cytokines such
as Interleukin-1b (IL-1b), IL- 6 and IL-8, play a role in the ischemic injury of the central nervous system.
TNF-? has adverse effects on ischemic brain tissue. The mechanism generated is a multicomplex process. In
other studies, an increase in TNF-? can actually have neuroprotective effects. This study aims to determine
the relation between the levels of the High Sensitivity TNF-? with clinical outcome in acute ischemic stroke.
Method : Thirty patients with acute ischemic stroke patients who admitted in Dr. Soetomo hospital Surabaya
during the period December 2011 to February 2012. 2 cc of vein blood for examination High sensitivity
TNF-? was drawn during admission from acute ischemic stroke. Clinical outcome in acute stroke was
measured by NIHSS score.
Results: From 30 research samples, the mean age of patients was 59.53 ± 11.51 years. The mean High
Sensitivity TNF-? level in the study subjects was 2 ± 0.99 pg / ml. NIHSS examination showed the median
value of the NIHSS was 5 with a range of 2-19. There is a correlation but not statistically significant with
the strength is very weak between High Sensitivity TNF-? with the NIHSS in patients with acute thrombotic
stroke (r = 0.100 and p = 0.600).
Conclusion: There is relationship between serum levels of High sensitivity TNF-? with clinical outcome in
acute ischemic stroke patients.

Author Biography

Mohammad Saiful Ardhi1 , Mohammad Saiful Islam1

1
Neurologist, Consultant Neurovascular, Department of Neurology, Faculty of Medicine, Universitas Airlangga,
Dr. Soetomo General Hospital Surabaya, (60131) Indonesia

Published

2020-12-31

How to Cite

Mohammad Saiful Ardhi1 , Mohammad Saiful Islam1. (2020). Relationship Between High Sensitivity TNF-? WITH clinical outcome During Admission In Acute Ischemic Stroke. Indian Journal of Forensic Medicine & Toxicology, 15(1), 1305-1308. https://doi.org/10.37506/ijfmt.v15i1.13595

Issue

Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology

Section

Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details

https://creativecommons.org/licenses/

CC BY

This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.

  1. The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
  1. The journal allows the author(s) to hold the copyright without restrictions.
  1. The journal allows the author(s) to retain publishing rights without restrictions