Efficacy and Safety of Sacral Neuromodulation in Treatment of Refractory Overactive Bladder


  • Mohammed Bassil Ismail1 , Wameedh Qays Abdullhussein2




Neuromodulation, OAB, UTI, incontinence


Background: Overactive bladder syndrome is a urinary disorder that occurs more frequently in women and
older people and is characterized by feeling an urge to urinate (sudden urge to urinate, with the feeling that
you cannot get to the bathroom in time), doing it many times throughout the day (more than six) or having
episodes of urinary incontinence (involuntary loss of urine) and nocturia (waking up several times during
the night to urinate). In addition, other secondary symptoms may also occur, such as headache, dry mouth or
blurred vision, among others. It is a problem that has a clear impact on the quality of life of those who suffer
it and that can lead them to significantly reduce their social activity and negatively condition their work.
Overactive bladder (OAB) is defined as urinary urgency with or without urgency urinary incontinence,
nocturia, and/or frequency in the absence of UTI or other obvious pathology. Sacral neuromodulation is a
newer surgical therapy for refractory OAB.
Aim of Study: Is to assess the sacral neuromodulation (SN) safety and efficacy in refractory overactive
bladder patients.
Patients and Methods: In the period from November 2015 to May 2017. the unit of neurogenic bladder
and neuromodulation in (Gazi Al_Harriry) surgical specialty hospital, medical city complex 27 patient aged
from (17—55) year old were complaining from refractory overactive bladder. All the 27 patients underwent
stage1 & stage2 SNS devices implantation.
Results: Patients of urgency incontinence (group1) demonstrated that the number of leak was significantly
reduced (p=0.01) after implantation of SN, (11.6_2.7) leak/day pre& post SN, numbers of pads (6.9 _ 0.8)
pad/day pre&post SN. Patients with urgency frequency (group 2), numbers of voids/day pre & post SN
implantation decreased significantly (p=0.01) (14.7 _ 6) voids /day. The voided volume increased significantly
(p=0.02) from (136.4 _ 371.8) ml/void. The urgency episodes were decreased significantly (p=0.01) from
(6.4 _ 2.1) episode/day. The complications occurred in 5 patients (18.5%). Two patients (7.4%) developed
pain after trauma to the back, lead migration, lack of efficacy of device, treated by reprogramming the
device, one patient (3.7%) get infection at the site of device implantation, SN was removed , there was one
female patient (3.7%) got pregnancy and devise was deactivated. One patient (3.7%) complaining from pain
and discomfort at the device site was treated conservatively.
Conclusion: Sacral neuromodulation is FDA approved as option for treatment of refractory OAB. There is
expanding of utilizing of SN in the past two decades. According to multiple studies in addition to our study
results. The sacral neuromodulation is safe and efficacious treatment option for refractory OAB.

Author Biography

Mohammed Bassil Ismail1 , Wameedh Qays Abdullhussein2

Lecturer, CABMS (Urology), College of Medicine/University of Baghdad,
Specialist CABMS (NEUROSURGERY), Medical City Complex, Baghdad



How to Cite

Mohammed Bassil Ismail1 , Wameedh Qays Abdullhussein2. (2020). Efficacy and Safety of Sacral Neuromodulation in Treatment of Refractory Overactive Bladder. Indian Journal of Forensic Medicine & Toxicology, 15(1), 1315-1321. https://doi.org/10.37506/ijfmt.v15i1.13597