The Interleukin-6 (rs1800797) Variant in Healthy Individuals at Medan City, North Sumatera Province
Keywords:Interleukin 6 (rs1800797), variant, gene, polymorphism, healthy
The Interleukin-6/IL6 (rs1800797) variant play a role in several diseases pathogenesis. The frequency
genotype of IL6 (rs1800797) varied based on different race, ethnicity, and underlying character in
population. This study aimed to assess the frequency of genotype and allele of IL6 (rs1800797) in healthy
individuals at Medan city, North Sumatera Province Province and this study can be used as a reference in
determining of several diseases for further studies. Genotyping of IL6 (rs1800797) in the promoter region
using polymerase chain reaction and restriction fragment length polymorphism method, analysis using FokI
restriction enzyme. This study showed that the genotype frequency of GG, GA, and AA were 95.8 %, 4.2
%, and 0 %, respectively. The allele frequency of G and A were 97.9 % and 2.1 %, respectively. The results
indicated that the homozygous wild-type (GG) of IL6 (rs1800797) was higher than the heterozygous mutant
(GA) and there was absent of homozygous mutant (AA) in this population. The frequency of G allele also
higher than A mutant allele.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions