The Interleukin-6 (rs1800797) Variant in Healthy Individuals at Medan City, North Sumatera Province

Authors

  • Mutiara Indah Sari1*, Siti Syarifah2 , Milahayati Daulay3 , Zaimah Z Tala4

DOI:

https://doi.org/10.37506/ijfmt.v15i1.13603

Keywords:

Interleukin 6 (rs1800797), variant, gene, polymorphism, healthy

Abstract

The Interleukin-6/IL6 (rs1800797) variant play a role in several diseases pathogenesis. The frequency
genotype of IL6 (rs1800797) varied based on different race, ethnicity, and underlying character in
population. This study aimed to assess the frequency of genotype and allele of IL6 (rs1800797) in healthy
individuals at Medan city, North Sumatera Province Province and this study can be used as a reference in
determining of several diseases for further studies. Genotyping of IL6 (rs1800797) in the promoter region
using polymerase chain reaction and restriction fragment length polymorphism method, analysis using FokI
restriction enzyme. This study showed that the genotype frequency of GG, GA, and AA were 95.8 %, 4.2
%, and 0 %, respectively. The allele frequency of G and A were 97.9 % and 2.1 %, respectively. The results
indicated that the homozygous wild-type (GG) of IL6 (rs1800797) was higher than the heterozygous mutant
(GA) and there was absent of homozygous mutant (AA) in this population. The frequency of G allele also
higher than A mutant allele.

Author Biography

Mutiara Indah Sari1*, Siti Syarifah2 , Milahayati Daulay3 , Zaimah Z Tala4

1
Senior Lecturer and Head of Department of Biochemistry, 2Senior Lecturer of Department of Pharmacology
and Therapeutics, 3
Senior Lecturer of Department of Physiology, 4
Senior Lecturer and Head of Departement of
Clinical Nutrition, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

Published

2020-12-31

How to Cite

Mutiara Indah Sari1*, Siti Syarifah2 , Milahayati Daulay3 , Zaimah Z Tala4. (2020). The Interleukin-6 (rs1800797) Variant in Healthy Individuals at Medan City, North Sumatera Province . Indian Journal of Forensic Medicine & Toxicology, 15(1), 1361-1366. https://doi.org/10.37506/ijfmt.v15i1.13603