Association of rs865429 C/T polymorphism in SOST gene with Coronary Heart Disease in Iraqi Type 2 Diabetes Mellitus Patients
Keywords:single nucleotide polymorphism, polymerase chain reaction restriction fragment length polymorphism, type 2diabetese mellitus, coronary artery diseases.
Sclerostin, encoded by the SOST gene, It has also been shown that sclerostin is expressed in aortic VSMC
(vascular smooth muscle) and upregulation of SOST gene has inhibitory effects on the aortic aneurysm
and atherosclerosis development. Aims: The current study aims to explore potential the association
between SOST gene single nucleotide polymorphisms (rs865429 C/T) and coronary artery diseases (CHD)
in type 2 diabetes mellitus (T2DM) patients, in addition to the effect of this SNP on the level of serum
sclerostin and other glycemic parameters. Material and methods: From the Iraqi population, we enrolled
300 T2DM patients (150 T2DM with CHD and 150 T2DM without CHD). Serum blood glucose, serum
insulin, HbA1C, and sclerostin were estimated. Genotyping for rs865429 C/T in SOST gene was achieved
by RFLP (polymerase chain reaction-restriction fragment length polymorphism). Results: T2DM patients
having CT + TT genotype included in the studied were at increased risk for CHD in T2DM (odd ratio:
0.4444 CI: 0.2800 to 0.7054) and related to a high serum sclerostin level in comparison with type 2 diabetic
patients with CC genotype. Conclusions: Type 2 diabetic patients with T allele who have elevated plasma
concentrations of sclerostin are at high risk for coronary artery diseases.
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