Genetic Modification of Mitochondrial DNA in Cancer Cells
Keywords:mtDNA, cancer, mutation, role mtDNA, energy source.
Mitochondria is one of the most energy source in the cells, in addition to DNA encoded to several genes
which relatively associated with several disease, researchers proved the role of mitochondrial in energy
demand to tumor cells in addition to mitochondrial DNA role in cancer initiation and development. The
present review explained different objectives related with the mitochondrial role in tumor incidence ;
these included Tumor cells energy demands, Mitochondrial Mutations redundancy and allocation, Genetic
disparate natural Selection in Tumor initiation, Mitochondrial Modifications Clinical Translations in Cancer,
Association Mitochondria, epigenetics and Cancer and finally Injury of Mitochondria in Cancer. The present
review concluded that the most important role of mitochondrial as cells an organelles for energy suppliers
to tumor cells metastasis and immorality also the mutations of mtDNA and their role in carcinogenesis were
well proved in different cancer types.
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