The Role of EMMPRIN in Perirenal Fat Invasion Clear Cell Renal Cell Carcinoma

Authors

  • Vira Yasmina Ramadhani1,2,3, Anny Setijo Rahaju4,5,6, Nila Kurniasari4,5,6

DOI:

https://doi.org/10.37506/ijfmt.v15i1.13645

Keywords:

Clear cell renal cell carcinoma, EMMPRIN, perirenal fat invasion

Abstract

Renal Cell Carcinoma (RCC) is a common malignancy of the kidney, and Clear Cell Renal Cell Carcinoma
(CCRCC) is the most common type. Accurate prediction of prognosis is valuable for therapy and follow
up. EMMPRIN is a transmembrane protein of the immunoglobulin family and is associated with tumour
proliferation, invasion and metastasis. This study aims to prove the role of EMMPRIN in perirenal fat
invasion CCRCC. This analytic observational study with a cross-sectional approach conducted in Anatomical
Pathology Institute of Dr. Soetomo Hospital, Surabaya that used 44 samples of paraffin blocks from radical
nephrectomy preparations for CCRCC patients at the period of January 2013-December 2018, which were
divided based on perirenal fat invasion status. The analyzed was using Spearman test. EMMPRIN expression
is positively correlated with perirenal fat invasiveness (p = 0.019) in clear cell renal cell carcinoma.
EMMPRIN expression is related with perirenal fat invasiveness, in clear cell renal cell carcinoma.

Author Biography

Vira Yasmina Ramadhani1,2,3, Anny Setijo Rahaju4,5,6, Nila Kurniasari4,5,6

1
Student, Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia,
2
Student, Universitas Airlangga Hospital, Surabaya, Indonesia, 3
Student, Dr. Soetomo General Academic Hospital,
Surabaya, Indonesia, 4Lecturer, Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga,
Surabaya, Indonesia, 5Lecturer, Universitas Airlangga Hospital, Surabaya, Indonesia, 6Lecturer, Dr. Soetomo
General Academic Hospital, Surabaya, Indonesia

Published

2020-12-31

How to Cite

Vira Yasmina Ramadhani1,2,3, Anny Setijo Rahaju4,5,6, Nila Kurniasari4,5,6. (2020). The Role of EMMPRIN in Perirenal Fat Invasion Clear Cell Renal Cell Carcinoma . Indian Journal of Forensic Medicine & Toxicology, 15(1), 1633-1639. https://doi.org/10.37506/ijfmt.v15i1.13645