Estimation of Interleukin-4 (IL-4) and Interleukin-6 (IL-6) Levels in Sera From Patients with Type 2 Diabetes Mellitus
Keywords:IL-6, interleukin-6; IL-4, interleukin-4; T2DM, type 2 diabetes mellitus, ELISA, the enzymelinked immunosorbent assay.
Type-2 diabetes mellitus is the most common chronic metabolic disorder characterized by elevation of
blood glucose concentration (hyperglycemia) due to defect in carbohydrate, lipid and protein metabolism.
Cytokines have an important role in impairing insulin signaling and selective destruction of insulin-producing
beta cells. Thus, the second type of diabetes can be characterized as an immune-mediated disease. This study
aimed to evaluate the serum levels of Interleukin-4 (IL-4) and Interleukin-6 (IL-6) of patients with type 2
diabetes mellitus among cases from Wasit province-Iraq. A total of 90 randomly selected subjects from
Wasit province – Iraq: (60) patients with T2DM, and (30) apparently healthy subjects with normal fasting
blood sugar as a control group. Enzyme-linked immunosorbent assay (ELISA) was used to measure the
levels of interleukin-4 IL-4 and interleukin -6 in sera from patients with type-2 diabetes mellitus. The results
of this study showed that IL-4 concentrations had a non-significant difference when compared patients with
type-2 diabetes mellitus with the control group (154 ± 7.00 versus (vs) 151.49 ± 21, P-value (P) = > 0.05).
While patients with T2DM revealed elevated serum levels of IL-6 compared to control group (B 637.1 ±
355.9 versus 266.3 ± 128.8, P = < 0.001).
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