Association of Gamma-GT Serum and Nerve Conduction Velocity of Nervus Peroneus Motor Vehicles on Diabetic Polyneuropathy Patients

Authors

  • Januar1 , Mudjiani Basuki2

DOI:

https://doi.org/10.37506/ijfmt.v15i1.13681

Keywords:

Polyneuropathy, Gamma GT, Motoric, Nerve Conduction Velocity

Abstract

Background and Objectives: Diabetic Polyneuropathy is one of the common complications of diabetes
mellitus (DM) and can lead to foot ulcers or amputation. The pathophysiology of Diabetic Polyneuropathy
includes several factors such as metabolic, vascular, autoimmune, oxidative stress and neurohormonal
growth-factor deficiency. The recent studies have suggested the use of serum gammaglutamyl transferase
(GGT) as an early marker of oxidative stress. Therefore, we investigated whether serum GGT may be useful
in predicting Diabetic Polyneuropathy.
Methods: The study was conducted in patients with diabetic polyneuropathy who meet the criteria for
inclusion and exclusion in neurological outpatient clinic and EMG room departments of Neurology
Dr.Soetomo General Hospital Surabaya consecutively started in June 2014 to April 2015.
Result: We obtained 20 study subjects (8 subjects with increased serum levels of gamma GT and 12 subjects
with normal serum levels of gamma GT). There was statistically no significant between serum levels of
gamma GT with motoric nerve conduction velocity (NCV) of peroneal nerve (p = 0.582 ; Odds ratio 0.600).
Conclusion: There was no relationship between elevated levels of serum gamma GT with decreased motor
nerve conductivity velocity peroneal nerve in patients with diabetic polyneuropathy.

Author Biography

Januar1 , Mudjiani Basuki2

1
Researcher of Department of Neurology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching
Hospital, Surabaya 60285, Indonesia, 2 Lecturer and Researcher of Department of Neurology, Faculty of Medicine,
Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya 60285, Indonesia

Published

2020-12-31

How to Cite

Januar1 , Mudjiani Basuki2. (2020). Association of Gamma-GT Serum and Nerve Conduction Velocity of Nervus Peroneus Motor Vehicles on Diabetic Polyneuropathy Patients. Indian Journal of Forensic Medicine & Toxicology, 15(1), 1859-1864. https://doi.org/10.37506/ijfmt.v15i1.13681