Guggulsterone Suppresses Ovalbumin- Induced Inflammation in Rat Asthmatic Model
Keywords:gugglsterone, asthma, anti-inflammatory activity , NF-kappaB
Background: Asthma is an inflammatory airway disease, which is characteristic by wheezing, chest
tightness, dyspnea and cough, all symptoms that are occupied with obstruction of respiratory airway. Aim:
investigate guggulsterone activity on improve inflammatory events that associated with asthma. Method:
48 healthy rats (albino, male) divided to 6 groups, rats were sensitized with OVA and preparation lung tissue
homogenate for measurement of inflammatory parameters by ELISA and RT-PCR. Also, preparation of lung
tissue for histopathological examination. Results: All parameters are significant reduction in treated group
with guggulsterone than sensitized group. Also, gugglsterone-treated group’s slides with less inflammatory
signs compared to sensitized group slide. Conclusion: Guggulsterone improve inflammatory events that
associated with asthma.
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