Guggulsterone Suppresses Ovalbumin- Induced Inflammation in Rat Asthmatic Model

Authors

  • Zainab H. Ahmed1 , Munaf H. Zalzala2, Manal A. Ibrahim1

DOI:

https://doi.org/10.37506/ijfmt.v15i1.13759

Keywords:

gugglsterone, asthma, anti-inflammatory activity , NF-kappaB

Abstract

Background: Asthma is an inflammatory airway disease, which is characteristic by wheezing, chest
tightness, dyspnea and cough, all symptoms that are occupied with obstruction of respiratory airway. Aim:
investigate guggulsterone activity on improve inflammatory events that associated with asthma. Method:
48 healthy rats (albino, male) divided to 6 groups, rats were sensitized with OVA and preparation lung tissue
homogenate for measurement of inflammatory parameters by ELISA and RT-PCR. Also, preparation of lung
tissue for histopathological examination. Results: All parameters are significant reduction in treated group
with guggulsterone than sensitized group. Also, gugglsterone-treated group’s slides with less inflammatory
signs compared to sensitized group slide. Conclusion: Guggulsterone improve inflammatory events that
associated with asthma.

Author Biography

Zainab H. Ahmed1 , Munaf H. Zalzala2, Manal A. Ibrahim1

1
Lecturer, Department of Pharmacology and Toxicology, College of Pharmacy, University of Basra, Basra, Iraq,
2 Assist of Professor, Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad,
Baghdad, Iraq

Published

2020-12-31

How to Cite

Zainab H. Ahmed1 , Munaf H. Zalzala2, Manal A. Ibrahim1. (2020). Guggulsterone Suppresses Ovalbumin- Induced Inflammation in Rat Asthmatic Model . Indian Journal of Forensic Medicine & Toxicology, 15(1), 2388-2395. https://doi.org/10.37506/ijfmt.v15i1.13759