Study the Role of Helicobacter Pylori Infection in a Group of Iraqi Patients with Colorectal Cancer
Keywords:colorectal cancer, Helicobacter pylori-Infection, Serum, Immunoglobulins
Background Increased developed of colorectal tumor may be linked with Helicobacter pylori. However, the
underlying mechanisms were still uncertain.
objective: Helicobacter pylori infection in the world, in particular in developing countries, is one of most
common chronic bacterial infections, This bacterium is responsible for many diseases such as gastritis,
peptic ulcer, lymphoma and in some patients may lead to gastric cancer, it is in the world has known 2nd
major cause of death from cancer. H.pylori infection may likely raise the risk of colorectal cancer, according
to recently published studies. The aimed of this study to detected the role of H. pylori in colorectal cancer.
Methods: Serum of 50 colorectal cancer and colorectal normal with positive H. pylori infection patients
were estimated by 14Urea breath test and 25 subjects with no any inflammatory disease as the control group.
from each patient were collected Blood samples to investigated of H. pylori specific immunoglobulin G
(IgG) and CagA IgG antibodies by using enzyme-linked immunosorbent assay (ELISA).
Results: A total of 50 patients in this study 25 had colorectal cancer and 25 had colorectal normal with H.
pylori infection (immunoglobulin G (IgG) P ? 0.01 and CagA IgG antibodies P < 0.01) were significantly
more prevalent in the patients with colorectal_ cancer and colorectal normal with Helicobacter pylori
_infection compared with the healthy controls (P= 0.00019, P= 0.00022 respectively) The relation was
statistically non-significant between the antibody seropositivity and gender but Highly significant with age.
Conclusion: The findings indicate that Helicobacter pylori_ infection can be regarded as a contributing
influence for progressive tumor in colorectal.
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