Evaluation of antioxidants capacity of non-enzymatic antioxidants and its effect in glucose level in diabetic patients
Keywords:Antioxidant, total antioxidant capacity, non-enzymatic antioxidants, diabetes
Background: Oxidative stress might participate in the pathophysiology of diabetes type 2. Systems of nonenzymatic antioxidants are made up of scavenging molecules that are formed endogenously.
The Study Objective: This study’s aims were evaluation of the non-enzymatic antioxidants and their effect
in levels of glucose among diabetic patients.
Methodology: A total of eighty patients with DM type 2 and forty healthy persons (control) were enrolled
within this study. Serum and plasma were obtained from collected blood samples. The Ferric Reducing
Ability of Plasma (FRAP) method was used for detection of the total antioxidant capacity (TAC). Ellman’s
method was used to determine the level of reduced glutathione. The serum CAT activity was detected by the
technique explained by Sinha.
Results: The findings revealed that, among diabetic groups, there was a significant elevation in glycosylated
hemoglobin and glucose levels; HbA1c and FBG levels were significantly higher; MDA, NO, LPI, TAC and
GSH showed significant greater values. The activity of SOD showed significantly greater mean value among
the control group.
Conclusion: The results suggest that antioxidants defense might be decreased in T2DM, as TAC levels
were decreased. The increased levels of MDA, NO, LPI, TAC and GSH were associated with oxidative
stress. Assessment of GSH could help in recognition of the extent of oxidative stress in diabetes as well as
prevention and control of diabetic complications.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions