The Association between Subclinical Hypothyroidism and Diabetic Retinopathy in the Patient with Type 2 Diabetic
Keywords:Diabetes mellitus, Subclinical hypothyroidism, Retinopathy
The present study aimed to determine the relationship between subclinical hypothyroidism and diabetic
retinopathy in patients with type 2 diabetes mellitus. In this cross-sectional analytical study, 150 patients
with type 2 diabetes mellitus were assessed. The eye fundus examination was performed using fundoscopy
to confirm or rule out retinopathy. Thyroid hormones were also measured by special kits to diagnose
subclinical hypothyroidism. The criteria for diagnosis of this disorder include the high serum thyrotropin
concentration (? 4mIU/L) plus normal serum free thyroxin levels. Statistical analyses were done using IBMSPSS. In the study, 34.66% suffered retinopathy. A total of 24.0% suffered subclinical hypothyroidism with
higher prevalence rate in those with retinopathy as compared with the group without retinopathy (p = 0.001).
Those with diabetic retinopathy also experienced longer duration of diabetes than those without this event.
(p = 0.006). Analysis show a significant role for type 2 diabetes mellitus (OR = 1.121, P = 0.003), and high
TSH level (OR = 1.342, P = 0.006) to predict diabetic retinopathy.This study showed an association between
hypothyroidism, diabetes and increased TSH with retinopathy. Retinopathy is significantly predicable with
the presence of subclinical hypothyroidism and longer duration of diabetes.
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