Medical Induction of First Trimester abortion by Misoprostol or Misoprostol with Letrozole
Keywords:Letrozole; Abortion, Induced; Misoprostol, Pregnancy, First rimester;
Background: Managing of abortion is an important subject in gynecology. Millions of patients had suffered
from spontaneous abortions that occur per year.
Objectives: The aim of this study was to compare the effect of misoprostol alone and misoprostol with
letrozole in the induction of abortion in the first trimester of pregnancy.
Patients and Methods: In a single –blind clinical trial ,128 female applicants for legal abortion within the
first trimester of pregnancy that referred to AL-Batool hospital , were divided in to two groups: intervention
(misoprostol with letrozole) and control groups (misoprostol alone). The complete abortion, drug-induced
side effects of misoprostol and letazole were noted and evaluated.
Results: The complete abortion rate was93.2% in intervention group and in68.7% in the control group
(misoprostol) only, which was significantly higher in intervention group (p = 0.001).
Abdominal pain in the intervention group is also significantly lower than that of the control group (p =
0.013). Intervention group also had significantly lower duration of bleeding rather than control group (p =
Conclusions: Based on our results, pretreatment with letrozole plus Misoprostol was more effective for
prompting abortion in the first trimester of pregnancy without increasing side effect compared to misoprostol
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