Canine-premolar Transposition, Family Pedigree and Related Dental Anomalies
Keywords:Canine, Transposition, genetic, dental anomaly, peg-shaped, hypodontia
Maxillary canine-premolar transposition is a rare and complicated dental anomaly that needs special
consideration by the orthodontist. The aim of the present study was to investigate the clinical features of
maxillary canine-premolar transposition and report the family pedigree to determine the mode of inheritance.
A cross-sectional study was performed on 39 patients having maxillary canine-premolar transposition in
which both clinical and radiographic examination were performed. Moreover, 112 family members were
clinically examined looking for canine transposition. Variables such as location, sex and the presence of
hypodontia and peg-shaped lateral incisors were investigated. The study found that unilateral transposition
(89.7%) was more common than bilateral occurrence (10.2%) affecting the left side (64.1%) more than the
right side (35.9%). Females were affected more than males (74.4% and 25.6% respectively). Congenitally
missing teeth were reported in 12.8% and lower second premolar was the most commonly missing tooth.
Peg-shaped maxillary lateral incisor was reported in 7.7% of the sample. Family pedigree confirmed the
presence of a history of transposition or ectopically positioned canine in 15.3% of the sample suggesting
an autosomal dominant inheritance of the trait. In conclusion this study suggested an association between
genetic factors and maxillary canine-premolar transposition. Further studies are required using genetic
testing to confirm the findings of the present study.
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