Argyrophilic Nucleolar Organizer Regions in Premalignant and Malignant Oral Lesion: A Quantitative and Qualitative Assessment
DOI:
https://doi.org/10.37506/ijfmt.v15i2.15048Keywords:
Argyrophilic nucleolar organizer regions, epithelial dysplasia, oral squamous cell carcinoma.Abstract
Background: Argyrophilic nucleolar organizer regions (AgNORs) has been considered to be useful in
diagnostic pathology, mainly to distinguish benign lesions from their malignant counterparts.
Aim: This study was done to evaluate the significance of various AgNOR parameters in differentiating
premalignant and malignant oral lesions.
Materials and Methods: The study was performed on thirty five archival tissues consisting of sample
comprised of five normal mucosa, fifteen premalignant lesions and fifteen malignant oral lesions. AgNORs
were assessed both quantitatively and qualitatively. The data were analyzed using ANOVA and Chi square
test.
Results: Quantitatively and qualitatively significant difference was noticed. Quantitatively significant
difference in the mean value of AgNORs noticed between the premalignant and malignant lesions. In terms
of qualitatively, the premalignant and malignant oral lesions differed significantly from normal mucosa.
Conclusion: To conclude, the AgNOR count is the most appropriate marker to differentiate between
premalignant and malignant oral lesions.
Downloads
Published
Issue
Section
License
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions