Argyrophilic Nucleolar Organizer Regions in Premalignant and Malignant Oral Lesion: A Quantitative and Qualitative Assessment

Authors

  • Shafali Singh
  • Seema Sharma
  • Manu Gupta
  • Akansha Singh

DOI:

https://doi.org/10.37506/ijfmt.v15i2.15048

Keywords:

Argyrophilic nucleolar organizer regions, epithelial dysplasia, oral squamous cell carcinoma.

Abstract

Background: Argyrophilic nucleolar organizer regions (AgNORs) has been considered to be useful in
diagnostic pathology, mainly to distinguish benign lesions from their malignant counterparts.
Aim: This study was done to evaluate the significance of various AgNOR parameters in differentiating
premalignant and malignant oral lesions.
Materials and Methods: The study was performed on thirty five archival tissues consisting of sample
comprised of five normal mucosa, fifteen premalignant lesions and fifteen malignant oral lesions. AgNORs
were assessed both quantitatively and qualitatively. The data were analyzed using ANOVA and Chi square
test.
Results: Quantitatively and qualitatively significant difference was noticed. Quantitatively significant
difference in the mean value of AgNORs noticed between the premalignant and malignant lesions. In terms
of qualitatively, the premalignant and malignant oral lesions differed significantly from normal mucosa.
Conclusion: To conclude, the AgNOR count is the most appropriate marker to differentiate between
premalignant and malignant oral lesions.

Author Biographies

  • Shafali Singh

    Senior Lecturer, Department of Oral Pathology & Microbiology, School of Dental Sciences, Sharda University,
    Greater Noida

  • Seema Sharma

    Professor & Head of Department, Department of Oral Pathology & Microbiology, Santosh Dental
    College, Ghaziabad

  • Manu Gupta

    Reader, Department of Oral Pathology & Microbiology, Santosh Dental College,
    Ghaziabad

  • Akansha Singh

    Consultant Physiotherapist at Private Clinic

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Published

2021-03-24

How to Cite

Argyrophilic Nucleolar Organizer Regions in Premalignant and Malignant Oral Lesion: A Quantitative and Qualitative Assessment. (2021). Indian Journal of Forensic Medicine & Toxicology, 15(2), 4318-4362. https://doi.org/10.37506/ijfmt.v15i2.15048