To Assess the Study of Pro- BNP, CPK -MB and Troponin Level in Acute Myocardial Infarction

Authors

  • Ranjit Ambad
  • Dattu Hawale
  • Pradip Jain

DOI:

https://doi.org/10.37506/ijfmt.v15i2.15086

Keywords:

AMI, N-terminal Pro-BNP, CPK-MB, Troponin I

Abstract

Introduction: One of the greatest causes of death and morbidity in the world is acute myocardial infarction
(AMI). Atherosclerotic coronary artery disease (CAD) with plaque erosion or breakup, causing transient,
partial or total arterial occlusion, is the most common cause of AMI. Without appropriate blood flow, the
heart cannot continue to function, and if it is severely compromised, death is inevitable. Simple and objective
measures of cardiac function are brain natriuretic peptide (BNP) levels. These measurements can be used to
diagnose heart failure, including diastolic dysfunction, and have been shown to save money by using them
in the emergency room setting. For the diagnosis of acute myocardial infarction, the most sensitive and most
precise measure available is creatine phosphokinase (CPK-MB). The main biomarker for AMI diagnosis is
cardiac troponin I. The level of troponin may also be elevated with important prognostic value in many other
disorders, including heart failure.
Methods: This study was a case-control study, conducted in the Medicine and cardiology Department at
DMMC & SMHRC, Nagpur in collaboration with ABVRH, Sawangi (Meghe) during Nov 2020 to Jan 2020.
Total 80 individuals were considered for the study, 40 each in case and 40 in control groups.
Results: As present study show the Pro-BNP Levels were increased significantly (P<0.001) in the AMI
(2200±601.30) as compared in controls (90.20±3.20). The mean values of serum CK-MB and troponin I
were significantly (P<0.001) higher in the AMI (165±47.21, 1.48±0.45) as compared to those in the healthy
controls (11.50±0.80± 3.250, 0.03±0.01) respectively.
Conclusions: These findings therefore indicate that the combined detection of CK-MB, Troponin I and NTPro-BNP levels will contribute significantly to the early diagnosis of AMI. It can also provide the clinic with
diagnostic evidence and thus reduce AMI mortality in the acute phase.

Author Biographies

  • Ranjit Ambad

    Associate Professor Dept. of Biochemistry Datta Meghe Medical College, Nagpur

  • Dattu Hawale

    Tutor Dept. of Biochemistry
    Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi Meghe Wardha

  • Pradip Jain

    Professor and HOD Dept. of Biochemistry Datta Meghe Medical College, Nagpur

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Published

2021-03-24

How to Cite

To Assess the Study of Pro- BNP, CPK -MB and Troponin Level in Acute Myocardial Infarction. (2021). Indian Journal of Forensic Medicine & Toxicology, 15(2), 4479-4483. https://doi.org/10.37506/ijfmt.v15i2.15086