Evaluation of Gingival Inflammation, Plasma IL-6, and TMJ Clicking after Masseters Muscle Botulinum Toxin Injection and Intra-Articular PRP Injection In Bruxism Patients
Keywords:Gingival Inflammation, IL-6, TMJ, botulinum toxin, PRP , Bruxism
In this study, thirty patients complaining of bruxism at night and hyperactivity masseters muscle causing TMJ
disk changes, TMJ clicking sound and all selected patient complaining of gingival inflammation as included
criteria, and 50-unit botulinum toxin type A were injected in both side of masseter muscle. Regarding to
T.M.J clicking sound there were three intervals of PRP injection for 3 months. The levels of IL-6 in the
blood samples measured by ELISA technique, this study proposed to investigate the plasma IL-6 level in
patient with early changes of T.M.J disorder and role of repetitive intraarticular PRP injection on the T.M.J
clicking sound and the effect of decreasing stress force microtruma of masseter muscle on gingival score in
previously diagnosed bruxism patient with gingival inflammation whether of causative factor of gingivitis.
The mean difference of plasma IL-6 in between patient and control (25.6 ± 4.2 and 23.8 ± 1.8) respectively.
There were highly significant differences in gingival index score of all sided of oral cavity after botox
intramuscular injection. Force stress muscle microtruma of bruxism patient considered a contributory factor
that increased gingival inflammation these fact suggested by botulinum toxin injection to decrease this force,
and highly statically difference on gingival score after injection and also, the intraarticular injection of PRP
in T.M.J disorder patient statically not affected on the clicking sound of joint as well as suggesting in our
research for further studies to appear the role of IL-6 in early joint changes locally as an experimental study
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