Serum Uric Acid Level in Oral Cancer Patients -Original Study
Keywords:Serum uric acid,High uric acid, Oral potentially malignant disorders,Squamous cell carcinoma, Oral cancer.
Background Uric acid is a result of the metabolic breakdown of purine digestion. Serum uric
acid ensures against carcinogenesis by means of its cell reinforcement properties and forestalls the
development of oxygen extremists. High blood groupings of uric acid can prompt gout and are related
with diabetes and development of kidney stones. Serum uric acid fixation mirror the harmony between
uric acid combination and discharge. Studies have indicated that high uric acid is a danger factor
for hypertension, diabetes and Cardio Vascular illness.Squamous cell carcinoma is characterized as
threatening epithelial neoplasm showing squamous separation as described by the development of keratin
or the bury cell spans. It also includestheinitialpresenceofaprecancerous lesion.Moreover,specificmedical
conditionscancontributetotheoral potentially malignant disordersprevalenceOral squamous cell
carcinoma is the most well-known neoplasm speaking to over 80% of all oral malignancy cases. Serum uric
acid has been proposed to be related with the danger of malignant growth and it was seen that raised degrees
of serum uric acid was related with an expanded disease frequency contrasted with typical qualities.
Aim and Objectives : The aim of this study is to evaluate the serum uric acid level in oral cancer patients,
to find out the association between low serum uric acid level and risk of squamous cell carcinoma and to
compare the serum uric acid levels in oral cancer patients with normal individuals.
Materials and Methods : This is a hospital based study to find out the uric acid level in oral cancer patients.
The participants were selected from the out patients, Department of Oral Pathology and Microbiology. The
study included a total numbe of 28 persons. Out of the 28 persons 15 oral cancer patients were selected for
the experimental group. The remaining 13 subjects were in the normal group.
Results : In this study, mean uric acid level in this stroke population with CAD is 6.37 mgs/dl and in those
without CAD is 5.00 mgs/dl and thus establishes a statistically significant relationship (‘p’0.0004). When
males and females are considered, males have a significant association with a ‘p’ value of 0.0003. The buccal
mucosa of the oral cavity was the most common involved site followed by the vestibule.
Conclusion : The studies showed that serum uric acid level was significantly lower in oral cancer patients
compared to the control group. Uric acid may prevent the formation of oxygen radicals and there by protect
against carcinogenesis. In human’s uric acid is the most abundant antioxidant and is an important intra
cellular free radical scavenger. Early detection of oral cancer and Habit should be controlled to reduce
mortality rates and help to provide successful cancer treatment.
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