Synthesis and Characterization of New Oxo-Aztedine ,Imidazoldine and Thiazolidine Rings on Creatinine and Evaluation of their Biological Activity
This work included preparation of new imine from the reaction of creatinine with aldehydes (4-nitro
benzaldehyde, 4- amino benzaldehyde, cinnamaldehyde) and ketone ( acetophenone ) in ethanol and the
presence of few drops glacial CH3COOH to obtain Schiff bases (1a,1b,1c,1d) Schiff bases were treated
with monochloroacetyl chloride to produced (2a,2b,2c,2d), with glycine to synthesis (3a,3b,3c,3d) and
with 2-mercaptoacetic acid to prepare (4a,4b,4c,4d). The Prepared compounds had beenmeasured by (FTIR,
and1HNMR ) spectroscopic techniques. Some of the derivatives were studied activity against antibacterial,
antifungal and antioxidant.
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